Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK7 | P50613 | 7/20 | 0.42 |
| ▸ | CCNH | P51946 | 7/20 | 0.42 |
| ▸ | MNAT1 | P51948 | 7/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.42 |
| ▸ | CDK9 | P50750 | 5/20 | 0.42 |
| ▸ | CCNK | O75909 | 5/20 | 0.42 |
| ▸ | CDK12 | Q9NYV4 | 5/20 | 0.42 |
| ▸ | CCNE1 | P24864 | 4/20 | 0.42 |
| ▸ | CDK2 | P24941 | 4/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.39 |
| ▸ | FLT3 | P36888 | 6/20 | 0.39 |
| ▸ | NRAS | P01111 | 3/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.35 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.34 |
| ▸ | CCND1 | P24385 | 1/20 | 0.34 |
| ▸ | CCND3 | P30281 | 1/20 | 0.34 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.34 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31000154 | 0.93 | CDK7 (0.41) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL24231485 | 0.87 | FLT3 (0.52) | CDK7CCNHMNAT1CCNT1CDK9 | |
| SCHEMBL31557799 | 0.85 | IRAK4 (0.47) | CDK7CCNHCDK2EIF2AK4FLT3 | |
| SCHEMBL24976238 | 0.85 | IRAK4 (0.47) | CDK7CCNHCDK2EIF2AK4FLT3 | |
| SCHEMBL24231346 | 0.82 | IRAK4 (0.55) | CDK7CCNHFLT3NRASIRAK4 | |
| SCHEMBL24976243 | 0.82 | IRAK4 (0.42) | CDK7CCNHEIF2AK4FLT3NRAS | |
| SCHEMBL31557811 | 0.82 | IRAK4 (0.42) | CDK7CCNHEIF2AK4FLT3NRAS | |
| SCHEMBL30621237 | 0.82 | IRAK4 (0.55) | CDK7CCNHFLT3NRASIRAK4 | |
| SCHEMBL25990958 | 0.82 | IRAK4 (0.55) | CDK7CCNHFLT3NRASIRAK4 | |
| SCHEMBL25992532 | 0.82 | FLT3 (0.42) | CDK7CCNHEIF2AK4FLT3NRAS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658659-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | Children's Hospital Medical Center (US) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024163764-A2 | MULTI-CYCLIC IRAK AND FLT3 INHIBITING COMPOUNDS AND USES THEREOF | CHILDREN'S HOSPITAL MEDICAL CENTER (US) | 2024-08-08 | — | — | WO | disclosed |