Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lifitegrast. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 known ✓ | P05107 | 20/20 | 1.00 |
| ▸ | ITGAL known ✓ | P20701 | 20/20 | 1.00 |
| ▸ | ICAM1 | P05362 | 20/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lifitegrast SCHEMBL2632068 | 1.00 | ITGB2 (1.00) | ITGB2ICAM1ITGALCYP2C9 | |
| Lifitegrast SCHEMBL29386183 | 1.00 | ITGB2 (1.00) | ITGB2ICAM1ITGALCYP2C9 | |
| Lifitegrast SCHEMBL22556043 | 1.00 | ITGB2 (1.00) | ITGB2ICAM1ITGALCYP2C9 | |
| Lifitegrast SCHEMBL29355715 | 1.00 | ITGB2 (1.00) | ITGB2ICAM1ITGALCYP2C9 | |
| Lifitegrast SCHEMBL13167919 | 1.00 | ITGB2 (1.00) | ITGB2ICAM1ITGALCYP2C9 | |
| SCHEMBL28561637 | 0.97 | ITGB2 (0.95) | ITGB2ICAM1ITGALCYP2C9 | |
| SCHEMBL15445331 | 0.96 | ITGB2 (0.92) | ITGB2ICAM1ITGALCYP2C9 | |
| SCHEMBL22929996 | 0.95 | ITGB2 (0.90) | ITGB2ICAM1ITGALCYP2C9 | |
| SCHEMBL19134124 | 0.95 | ITGB2 (0.90) | ITGB2ICAM1ITGALCYP2C9 | |
| SCHEMBL4756175 | 0.95 | ITGB2 (0.90) | ITGB2ICAM1ITGALCYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025093739-A1 | SEMIFLUORINATED ALKANE COMPOSITIONS COMPRISING LIFITEGRAST | NOVALIQ GMBH (DE) | 2025-05-08 | — | — | WO | disclosed |
| CN-118684605-A | Preparation of ritgasan Process for the preparation of intermediates | 山东新时代药业有限公司 | 2024-09-24 | — | — | CN | disclosed |
| CN-118420572-A | Synthesis method of medicine intermediate benzofuran-6-carboxylic acid | 山东新时代药业有限公司 | 2024-08-02 | — | — | CN | disclosed |
| CN-118420530-A | Synthesis method of ritalst intermediate | 山东新时代药业有限公司 | 2024-08-02 | — | — | CN | disclosed |