Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 14/20 | 0.49 |
| ▸ | ATM | Q13315 | 14/20 | 0.49 |
| ▸ | ATR | Q13535 | 6/20 | 0.49 |
| ▸ | MELK | Q14680 | 2/20 | 0.49 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.48 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | MTOR | P42345 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22963983 | 1.00 | KCNH2 (0.49) | KCNH2ATMATRMELKLRRK2 | |
| SCHEMBL22964200 | 0.84 | MELK (0.47) | KCNH2ATMATRMELKLRRK2 | |
| SCHEMBL29725421 | 0.84 | MELK (0.47) | KCNH2ATMATRMELKLRRK2 | |
| SCHEMBL27242853 | 0.82 | LRRK2 (0.56) | KCNH2ATMATRMELKLRRK2 | |
| SCHEMBL22964252 | 0.81 | GSK3B (0.44) | KCNH2ATMATRMELKLRRK2 | |
| SCHEMBL29725480 | 0.81 | GSK3B (0.44) | KCNH2ATMATRMELKLRRK2 | |
| SCHEMBL27242928 | 0.80 | AURKA (0.39) | KCNH2ATM | |
| SCHEMBL27242913 | 0.80 | LRRK2 (0.70) | KCNH2ATMATRMELKLRRK2 | |
| SCHEMBL22964215 | 0.80 | LRRK2 (0.52) | MELKLRRK2 | |
| SCHEMBL29725376 | 0.80 | LRRK2 (0.52) | MELKLRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12492186-B2 | Bicyclic heterocyclic compounds useful as IRAK4 inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2025-12-09 | — | — | US | claimed |
| CN-114174279-B | Bicyclic heterocyclic compounds useful as IRAK4 inhibitors | 百时美施贵宝公司 | 2024-07-02 | — | — | CN | claimed |
| CN-114174279-B | Bicyclic heterocyclic compounds useful as IRAK4 inhibitors | 百时美施贵宝公司 | 2024-07-02 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12492186-B2 | Bicyclic heterocyclic compounds useful as IRAK4 inhibitors | IRAK4, IRAK3, IRAK1 | KCNH2 2792/4885ATM 701/4885ATR 586/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.