Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.83 |
| ▸ | TP53 | P04637 | 4/20 | 0.83 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.83 |
| ▸ | LMNA | P02545 | 3/20 | 0.83 |
| ▸ | HTT | P42858 | 1/20 | 0.83 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.83 |
| ▸ | POLB | P06746 | 1/20 | 0.70 |
| ▸ | GAA | P10253 | 2/20 | 0.70 |
| ▸ | HPGD | P15428 | 2/20 | 0.70 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.70 |
| ▸ | USP2 | O75604 | 1/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.70 |
| ▸ | CASP1 | P29466 | 1/20 | 0.70 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.70 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.70 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.70 |
| ▸ | P4HB | P07237 | 2/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2153135 | 0.92 | MAPT (0.85) | MAPTTP53KDM4ELMNAHTT | |
| SCHEMBL13836495 | 0.91 | MAPT (0.87) | MAPTTP53KDM4ELMNAHTT | |
| SCHEMBL13836369 | 0.91 | MAPT (0.87) | MAPTTP53KDM4ELMNAHTT | |
| SCHEMBL2153142 | 0.91 | MAPT (1.00) | MAPTTP53KDM4ELMNAHTT | |
| SCHEMBL31023243 | 0.91 | MAPT (1.00) | MAPTTP53KDM4ELMNAHTT | |
| SCHEMBL6721108 | 0.89 | MAPT (0.83) | MAPTTP53KDM4ELMNAHTT | |
| SCHEMBL2153383 | 0.89 | MAPT (0.83) | MAPTTP53KDM4ELMNAHTT | |
| SCHEMBL2153056 | 0.89 | MAPT (0.83) | MAPTTP53KDM4ELMNAHTT | |
| SCHEMBL31023222 | 0.89 | MAPT (0.87) | MAPTTP53KDM4ELMNAHTT | |
| SCHEMBL2153302 | 0.87 | MAPT (0.80) | MAPTTP53KDM4ELMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240299400-A1 | Transcription Factor GLI1 Inhibitors and Uses Thereof | UNIVERSITY OF CONNECTICUT (US) | 2024-09-12 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240299400-A1 | Transcription Factor GLI1 Inhibitors and Uses Thereof | GLI1, GLI2, SHH | MAPT 3866/4885TP53 290/4885KDM4E 588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.