SCHEMBL31024714

SCHEMBL31024714

COC(=O)c1cc(O)c(I)cc1C(=O)OC

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CA12 O43570 5/20 0.50
CA1 P00915 5/20 0.50
CA2 P00918 5/20 0.50
CA7 P43166 5/20 0.50
CA9 Q16790 5/20 0.50
CA14 Q9ULX7 5/20 0.50
PDK2 Q15119 1/20 0.50
PDK4 Q16654 1/20 0.50
LMNA P02545 2/20 0.48
TSHR P16473 1/20 0.48
CFTR P13569 2/20 0.47
GAA P10253 4/20 0.47
KDM4E B2RXH2 3/20 0.45
XDH P47989 2/20 0.45
POLB P06746 2/20 0.45
NFKB1 P19838 1/20 0.45
GFER P55789 1/20 0.45
NFKB2 Q00653 1/20 0.45
RELA Q04206 1/20 0.45
FUT7 Q11130 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25340450 1.00 CA12 (0.50) CA12CA1CA2CA7CA9
SCHEMBL15903170 0.87 CFTR (0.53) CA12CA1CA2CA7CA9
SCHEMBL30345042 0.86 CA12 (0.46) CA12CA1CA2CA7CA9
SCHEMBL25155265 0.86 CA12 (0.46) CA12CA1CA2CA7CA9
SCHEMBL1764082 0.86 CA12 (0.46) CA12CA1CA2CA7CA9
SCHEMBL17892934 0.85 CA12 (0.44) CA12CA1CA2CA7CA9
SCHEMBL31431621 0.85 CA1 (0.44) CA12CA1CA2CA7CA9
SCHEMBL31187062 0.85 CA12 (0.44) CA12CA1CA2CA7CA9
SCHEMBL31216058 0.85 CFTR (0.58) CA12CA1CA2CA7CA9
SCHEMBL10200826 0.85 CFTR (0.46) CA12CA1CA2CA7CA9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4656642-A1 ESTROGEN RECEPTOR PROTEOLYSIS TARGETING CHIMERA COMPOUND AND USE THEREOF GAN & LEE PHARM CO., LTD (CN) 2025-12-03 EP disclosed
WO-2025026283-A1 COMPOUND FOR SELECTIVELY DEGRADING SMARCA2/4 AND USE THEREOF 甘李药业股份有限公司 2025-02-06 WO disclosed
CN-118632848-A Cerebellar protein E3 ubiquitin ligase inhibitors 甘李药业股份有限公司 2024-09-10 CN disclosed
WO-2024156294-A1 ESTROGEN RECEPTOR PROTEOLYSIS TARGETING CHIMERA COMPOUND AND USE THEREOF 甘李药业股份有限公司 2024-08-02 WO disclosed