Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 2/20 | 0.39 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.34 |
| ▸ | TYK2 | P29597 | 3/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | JAK3 | P52333 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.33 |
| ▸ | GSK3B | P49841 | 1/20 | 0.33 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31026272 | 0.88 | XPO1 (0.35) | XPO1MDM2CHEK1ABL1RORC | |
| SCHEMBL31026269 | 0.84 | XPO1 (0.42) | XPO1TYK2JAK2JAK1JAK3 | |
| SCHEMBL31026251 | 0.81 | XPO1 (0.38) | XPO1CHEK1ABL1KMT2AKDM4E | |
| SCHEMBL31026267 | 0.81 | KDM4E (0.38) | XPO1TYK2JAK2JAK1MAP4K4 | |
| SCHEMBL25853864 | 0.80 | XPO1 (0.48) | XPO1MDM2TYK2JAK2JAK1 | |
| SCHEMBL31026253 | 0.80 | XPO1 (0.37) | XPO1CHEK1KMT2AKDM4ENPC1 | |
| SCHEMBL31026263 | 0.79 | XPO1 (0.38) | XPO1KMT2AKDM4ENPC1LMNA | |
| SCHEMBL31026275 | 0.78 | XPO1 (0.36) | XPO1KMT2AKDM4ENPC1LMNA | |
| SCHEMBL31026273 | 0.78 | XPO1 (0.37) | XPO1KMT2AKDM4ENPC1LMNA | |
| SCHEMBL31026247 | 0.78 | XPO1 (0.37) | XPO1ABL1MCHR1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4635942-A1 | QUINOLINE DERIVATIVE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF | Jiangsu Carephar Pharmaceutical Co., Ltd (CN) | 2025-10-22 | — | — | EP | disclosed |
| WO-2024152743-A1 | QUINOLINE DERIVATIVE COMPOUNDS OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF | 江苏柯菲平医药股份有限公司 | 2024-07-25 | — | — | WO | disclosed |
| CN-118373771-A | Quinoline derivative compound or pharmaceutically acceptable salt thereof, and preparation method and application thereof | 江苏柯菲平医药股份有限公司 | 2024-07-23 | — | — | CN | disclosed |