SCHEMBL31026537

SCHEMBL31026537

CC(C)(C)[Si](C)(C)Oc1cnc(F)c(C=O)c1

nearest known ligand 0.36

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
CA12 O43570 4/20 0.36
CA1 P00915 4/20 0.36
CA9 Q16790 4/20 0.36
ALOX5AP P20292 2/20 0.32
FEN1 P39748 2/20 0.32
PREP P48147 2/20 0.32
APLNR P35414 2/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16811712 0.78 ERN1 (0.44)
SCHEMBL1620647 0.76 CA12 (0.47) CA12CA1CA9PREPAPLNR
SCHEMBL29993848 0.76 CA12 (0.47) CA12CA1CA9PREPAPLNR
SCHEMBL2253527 0.76 CA12 (0.39) CA12CA1CA9PREPAPLNR
SCHEMBL29180817 0.75 PRKDC (0.38) CA12CA1CA9PREPAPLNR
SCHEMBL17494765 0.75 CA12 (0.46) CA12CA1CA9PREPAPLNR
SCHEMBL5882957 0.75 CA12 (0.36) CA12CA1CA9PREP
SCHEMBL30772161 0.75 PRKDC (0.38) CA12CA1CA9PREPAPLNR
SCHEMBL31026531 0.74 CA12 (0.33) CA12CA1CA9ALOX5APFEN1
SCHEMBL31026543 0.74 SOS1 (0.35) CA12CA1CA9ALOX5APFEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4660183-A1 NAV1.7- AND/OR NAV1.8-INHIBITING PHENOLIC COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS Eurofarma Laboratórios S.A. (BR) 2025-12-10 EP disclosed
WO-2024159286-A1 NAV1.7- AND/OR NAV1.8-INHIBITING PHENOLIC COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS EUROFARMA LABORATÓRIOS S.A. (BR) 2024-08-08 WO disclosed
WO-2024159285-A1 NAV1.7- AND/OR NAV1.8-INHIBITING ARYL PYRIDINE COMPOUNDS, PROCESSES FOR THE PREPARATION THEREOF, COMPOSITIONS, USES, METHODS FOR TREATMENT USING SAME, AND KITS EUROFARMA LABORATÓRIOS S.A. (BR) 2024-08-08 WO disclosed