SCHEMBL31027449

SCHEMBL31027449

N#Cc1cc2cc(CN3CCC4(CC3)CN(c3ncnc5ccc(OC(F)(F)F)cc35)C4)ccc2[nH]1

nearest known ligand 0.47

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ GPR183 P32249 1/20 0.47
▸ MEN1 O00255 9/20 0.43
▸ KMT2A Q03164 3/20 0.43
▸ AKT2 P31751 2/20 0.36
▸ KIT P10721 4/20 0.36
▸ HTT P42858 1/20 0.36
▸ RUNX1 Q01196 1/20 0.35
▸ PDE3B Q13370 1/20 0.34
▸ PDE3A Q14432 1/20 0.34
▸ ACHE P22303 1/20 0.34
▸ BACE1 P56817 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25717304 0.88 MEN1 (0.50) MEN1KMT2AHTT
SCHEMBL30405805 0.88 MEN1 (0.50) MEN1KMT2AHTT
Hydrochloric Acid SCHEMBL30406250 0.88 MEN1 (0.49) MEN1KMT2AHTT
SCHEMBL25717282 0.87 MEN1 (0.42) GPR183MEN1KMT2AHTTACHE
SCHEMBL31027442 0.87 MEN1 (0.44) GPR183MEN1KMT2AHTTACHE
SCHEMBL31578660 0.83 MEN1 (0.47) MEN1KMT2AHTT
SCHEMBL24939735 0.79 MEN1 (0.46) GPR183MEN1KMT2A
SCHEMBL24940485 0.75 MEN1 (0.48) GPR183MEN1KMT2A
SCHEMBL24940445 0.75 MEN1 (0.64) MEN1KMT2A
SCHEMBL25437860 0.75 MEN1 (0.52) MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250163061-A1 INHIBITORS OF MENIN-MLL INTERACTION BALA THERAPEUTICS, INC. 2025-05-22 — — US claimed
CN-118647378-A Inhibitors of Mei Nen protein interaction with MLL 巴拉疗法公司 2024-09-13 — — CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250163061-A1 INHIBITORS OF MENIN-MLL INTERACTION MLLT1, MEN1, BMI1 GPR183 2574/4885MEN1 2/4885KMT2A 8/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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