Rhapontigenin

Rhapontigenin

SCHEMBL31028358

COc1ccc(/C=C/c2cc(O)cc(O)c2)cc1OC

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A1 P04798 7/20 1.00
PTGS1 P23219 3/20 1.00
PTGS2 P35354 3/20 1.00
TTR P02766 2/20 0.77
APP P05067 2/20 0.71
CYP1B1 Q16678 6/20 0.68
NQO2 P16083 1/20 0.68
ABCG2 Q9UNQ0 1/20 0.68
MYC P01106 1/20 0.68
TUBB1 Q9H4B7 4/20 0.65
TUBB4A P04350 2/20 0.65
TUBB P07437 2/20 0.65
TUBA3C P0DPH7 2/20 0.65
TUBA1B P68363 2/20 0.65
TUBA4A P68366 2/20 0.65
TUBB4B P68371 2/20 0.65
TUBB3 Q13509 2/20 0.65
TUBB2A Q13885 2/20 0.65
TUBB8 Q3ZCM7 2/20 0.65
TUBA3E Q6PEY2 2/20 0.65

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Rhapontigenin SCHEMBL19433130 1.00 CYP1A1 (1.00) CYP1A1PTGS1PTGS2TTRAPP
Rhapontigenin SCHEMBL10307426 1.00 CYP1A1 (1.00) CYP1A1PTGS1PTGS2TTRAPP
SCHEMBL1815698 0.89 CYP1A1 (0.79) CYP1A1PTGS1PTGS2TTRAPP
SCHEMBL30940355 0.89 CYP1A1 (0.79) CYP1A1PTGS1PTGS2TTRAPP
SCHEMBL1815699 0.89 CYP1A1 (0.79) CYP1A1PTGS1PTGS2TTRAPP
SCHEMBL9586847 0.88 CYP1A1 (0.80) CYP1A1PTGS1PTGS2TTRAPP
SCHEMBL9431599 0.88 CYP1A1 (0.80) CYP1A1PTGS1PTGS2TTRAPP
SCHEMBL14782177 0.87 TTR (1.00) CYP1A1PTGS1PTGS2TTRAPP
SCHEMBL13004148 0.87 TTR (1.00) CYP1A1PTGS1PTGS2TTRAPP
SCHEMBL1486818 0.87 APP (0.93) CYP1A1PTGS1PTGS2TTRAPP

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4655410-A2 O-METHYLATION OF PHENOLIC SUBSTANCES VIA FUNGAL O-METHYLTRANSFERASE Symrise AG (DE) 2025-12-03 EP claimed
WO-2024156359-A1 O-METHYLATION OF PHENOLIC SUBSTANCES VIA FUNGAL O-METHYLTRANSFERASE SYMRISE AG (DE) 2024-08-02 WO claimed
WO-2024156879-A2 O-METHYLATION OF PHENOLIC SUBSTANCES VIA FUNGAL O-METHYLTRANSFERASE SYMRISE AG (DE) 2024-08-02 WO claimed
EP-4747367-A1 NEW ENZYMES FOR THE MANUFACTURING OF 4'-O-METHYLATED PHENOLIC SUBSTANCES Symrise AG (DE) 2026-05-27 EP disclosed
EP-4655410-A2 O-METHYLATION OF PHENOLIC SUBSTANCES VIA FUNGAL O-METHYLTRANSFERASE Symrise AG (DE) 2025-12-03 EP disclosed
WO-2025017042-A1 NEW ENZYMES FOR THE MANUFACTURING OF 4'-O-METHYLATED PHENOLIC SUBSTANCES SYMRISE AG (DE) 2025-01-23 WO disclosed
WO-2025016533-A1 NEW ENZYMES FOR THE MANUFACTURING OF 4'-O-METHYLATED PHENOLIC SUBSTANCES SYMRISE AG (DE) 2025-01-23 WO disclosed
WO-2024156359-A1 O-METHYLATION OF PHENOLIC SUBSTANCES VIA FUNGAL O-METHYLTRANSFERASE SYMRISE AG (DE) 2024-08-02 WO disclosed
WO-2024156879-A2 O-METHYLATION OF PHENOLIC SUBSTANCES VIA FUNGAL O-METHYLTRANSFERASE SYMRISE AG (DE) 2024-08-02 WO disclosed