Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLQ | O75417 | 3/20 | 0.67 |
| ▸ | DHODH | Q02127 | 2/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 4/20 | 0.40 |
| ▸ | CTSA | P10619 | 3/20 | 0.39 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | PLK4 | O00444 | 1/20 | 0.36 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | GNAI2 | P04899 | 1/20 | 0.36 |
| ▸ | LCK | P06239 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | HCK | P08631 | 1/20 | 0.36 |
| ▸ | ROS1 | P08922 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31032086 | 0.90 | POLQ (0.68) | POLQDHODHENPP1GPBAR1LRRK2 | |
| SCHEMBL22717543 | 0.83 | POLQ (0.47) | POLQDHODH | |
| SCHEMBL30017361 | 0.82 | POLQ (0.47) | POLQDHODHCTSAGPBAR1MAP4K1 | |
| SCHEMBL24770176 | 0.82 | POLQ (0.47) | POLQDHODHCTSAGPBAR1MAP4K1 | |
| SCHEMBL24769156 | 0.81 | POLQ (1.00) | POLQ | |
| SCHEMBL24500936 | 0.78 | POLQ (0.44) | POLQDHODHCTSAGPBAR1MAP4K1 | |
| SCHEMBL29694869 | 0.78 | POLQ (0.44) | POLQDHODHCTSAGPBAR1MAP4K1 | |
| SCHEMBL29229549 | 0.77 | POLQ (0.41) | POLQLCK | |
| SCHEMBL25261705 | 0.76 | AXL (0.44) | POLQDHODH | |
| SCHEMBL24501039 | 0.75 | POLQ (0.61) | POLQDHODHCTSAGPBAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240287080-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO.4) LIMITED (GB) | 2024-08-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240287080-A1 | O-LINKED THIADIAZOLYL COMPOUNDS AS DNA POLYMERASE THETA INHIBITORS | POLQ, POLK, POLB | POLQ 1/4885DHODH 210/4885ENPP1 333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.