Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 1/20 | 0.49 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.40 |
| ▸ | GHSR | Q92847 | 4/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.39 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.39 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.39 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.39 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.39 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31702739 | 0.94 | KLK7 (0.46) | KLK7HCRTR2MEN1KMT2APARP1 | |
| SCHEMBL29177532 | 0.90 | PARP1 (0.47) | KLK7HCRTR2MEN1KMT2APARP1 | |
| SCHEMBL29177530 | 0.88 | HCRTR2 (0.61) | HCRTR2GPR119 | |
| SCHEMBL29177533 | 0.88 | HCRTR2 (0.61) | HCRTR2GPR119 | |
| SCHEMBL30674679 | 0.88 | HCRTR2 (0.46) | KLK7HCRTR2GHSRPRMT5GPR119 | |
| SCHEMBL29229139 | 0.86 | KLK7 (0.46) | KLK7HCRTR2MEN1KMT2APARP1 | |
| SCHEMBL29229186 | 0.86 | KLK7 (0.46) | KLK7HCRTR2MEN1KMT2APARP1 | |
| SCHEMBL31484612 | 0.84 | HCRTR2 (0.44) | KLK7HCRTR2STSGHSRPRMT5 | |
| SCHEMBL30674574 | 0.83 | HCRTR2 (0.51) | HCRTR2GPR119 | |
| SCHEMBL973127 | 0.82 | KLK7 (0.49) | KLK7PARP1STSPSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4658660-A1 | MACROCYCLIC OREXIN RECEPTOR AGONISTS AND USES THEREOF | Jazz Pharmaceuticals Ireland Limited (IE) | 2025-12-10 | — | — | EP | disclosed |
| WO-2024160822-A1 | MACROCYCLIC OREXIN RECEPTOR AGONISTS AND USES THEREOF | JAZZ PHARMACEUTICALS IRELAND LIMITED (IE) | 2024-08-08 | — | — | WO | disclosed |