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SCHEMBL31047992

SCHEMBL31047992

C[Si](C)(C)CCOCN1C(=O)CCC(N2C(=O)c3ccc([N+](=O)[O-])cc3C2=O)C1=O

nearest known ligand 0.49

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 1/20 0.49
▸ CRBN Q96SW2 1/20 0.49
▸ ACHE P22303 6/20 0.42
▸ ALOX5 P09917 1/20 0.37
▸ KMT2A Q03164 1/20 0.36
▸ RPS6KA2 Q15349 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21196586 0.85 CRBN (0.46) DDB1CRBN
SCHEMBL25833431 0.85 CRBN (0.46) DDB1CRBN
SCHEMBL31540198 0.84 DDB1 (0.40) DDB1CRBN
SCHEMBL31047957 0.82 DDB1 (0.51) DDB1CRBNACHEKMT2A
SCHEMBL21402703 0.82 DDB1 (0.53) DDB1CRBNACHEALOX5KMT2A
SCHEMBL31188107 0.81 CRBN (0.39) DDB1CRBNKMT2A
SCHEMBL25833437 0.81 CRBN (0.39) DDB1CRBNKMT2A
SCHEMBL31047991 0.81 ALOX5AP (0.32) DDB1CRBN
SCHEMBL31291572 0.80 DDB1 (0.45) DDB1CRBN
SCHEMBL26996408 0.80 DDB1 (0.52) DDB1CRBNACHEKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024178067-A9 CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2025-02-06 — — WO disclosed
WO-2024178067-A1 CHIMERIC DEGRADERS OF CYCLIN-DEPENDENT KINASE 9 AND USES THEREOF MASSACHUSETTS INSTITUTE OF TECHNOLOGY (US) 2024-08-29 — — WO disclosed