Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 3/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | KRAS | P01116 | 11/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31048936 | 0.90 | JAK1 (0.37) | JAK1JAK2TYK2JAK3HDAC1 | |
| SCHEMBL31048929 | 0.85 | JAK1 (0.39) | JAK1JAK2TYK2JAK3KRAS | |
| SCHEMBL31049009 | 0.82 | JAK1 (0.40) | JAK1JAK2TYK2JAK3KRAS | |
| SCHEMBL31049087 | 0.82 | KRAS (0.46) | KRASMAPK3MAPK1 | |
| SCHEMBL31048860 | 0.81 | KRAS (0.39) | JAK1JAK2TYK2JAK3KRAS | |
| SCHEMBL31049243 | 0.79 | JAK1 (0.36) | JAK1JAK2TYK2JAK3KRAS | |
| SCHEMBL31049015 | 0.78 | KRAS (0.40) | JAK1JAK2TYK2JAK3KRAS | |
| SCHEMBL31048923 | 0.78 | KRAS (0.40) | JAK1JAK2TYK2JAK3KRAS | |
| SCHEMBL31049114 | 0.78 | JAK1 (0.38) | JAK1JAK2TYK2JAK3KRAS | |
| SCHEMBL31049053 | 0.76 | JAK1 (0.47) | JAK1JAK2TYK2JAK3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024167922-A2 | HETEROCYCLIC COMPOUNDS AS NRAS INHIBITORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-08-15 | — | — | WO | disclosed |