Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 18/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.32 |
| ▸ | RAF1 | P04049 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31048810 | 0.92 | KRAS (0.39) | KRASRETMAPK3MAPK1GPR119 | |
| SCHEMBL31048964 | 0.91 | RET (0.32) | KRASRETGPR119 | |
| SCHEMBL31049109 | 0.91 | KRAS (0.37) | KRASRETMAPK3MAPK1GPR119 | |
| SCHEMBL31048861 | 0.84 | KRAS (0.39) | KRASRETMAPK3MAPK1GPR119 | |
| SCHEMBL31048987 | 0.84 | — | — | |
| SCHEMBL31049099 | 0.83 | JAK1 (0.34) | KRASRETMAPK3MAPK1GPR119 | |
| SCHEMBL31048860 | 0.83 | KRAS (0.39) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL31048832 | 0.83 | KRAS (0.38) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL31048774 | 0.82 | KRAS (0.36) | KRASMAPK3MAPK1RAF1 | |
| SCHEMBL31048923 | 0.81 | KRAS (0.40) | KRASMAPK3MAPK1RAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024167922-A2 | HETEROCYCLIC COMPOUNDS AS NRAS INHIBITORS | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2024-08-15 | — | — | WO | disclosed |