SCHEMBL31049404

SCHEMBL31049404

CC1(NS(=O)(=O)c2cc(F)c3ncc(-c4nnc(C(F)F)o4)n3c2)COC1

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
PARG Q86W56 5/20 0.38
ALOX5AP P20292 1/20 0.34
FEN1 P39748 1/20 0.34
HDAC6 Q9UBN7 14/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31049451 0.93 PARG (0.45) PARGHDAC6
SCHEMBL31049432 0.85 PARG (0.40) PARGALOX5APFEN1HDAC6
SCHEMBL31049551 0.80 HDAC6 (0.37) HDAC6
SCHEMBL31049307 0.73 PARG (0.39) PARGHDAC6
SCHEMBL30967345 0.73 PARG (0.45) PARG
SCHEMBL31315459 0.73 PARG (0.38) PARGALOX5APFEN1
SCHEMBL31049397 0.72 HDAC6 (0.35) HDAC6
SCHEMBL31024588 0.72 PIK3CD (0.38) PARGALOX5APFEN1
SCHEMBL31049427 0.69 PARG (0.39) PARGALOX5APFEN1
SCHEMBL31024581 0.66 PARG (0.41) PARG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024173453-A1 HETEROARYL-SUBSTITUTED IMIDAZOPYRIDINE COMPOUNDS IDEAYA BIOSCIENCES, INC. (US) 2024-08-22 WO disclosed