Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 2/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | OXER1 | Q8TDS5 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 5/20 | 0.37 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | PPARD | Q03181 | 1/20 | 0.34 |
| ▸ | PPARA | Q07869 | 1/20 | 0.34 |
| ▸ | PDE5A | O76074 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL571591 | 0.76 | HSD17B3 (0.56) | ALDH1A1MAPTTBXAS1HDAC3HDAC4 | |
| SCHEMBL21791369 | 0.76 | HSD17B3 (0.56) | ALDH1A1MAPTTBXAS1HDAC3HDAC4 | |
| SCHEMBL571592 | 0.76 | HSD17B3 (0.56) | ALDH1A1MAPTTBXAS1HDAC3HDAC4 | |
| SCHEMBL19582800 | 0.75 | GRIK1 (0.49) | PPARGFFAR1ALDH1A1MAPTCYP19A1 | |
| SCHEMBL13870216 | 0.75 | KMT2A (0.62) | PPARGFFAR1ALDH1A1MAPTCYP19A1 | |
| SCHEMBL20545659 | 0.75 | AKR1C3 (0.53) | ALDH1A1MAPTAKR1C3AKR1C4KMT2A | |
| SCHEMBL3938646 | 0.74 | APP (0.36) | AKR1C3AKR1C4KMT2A | |
| SCHEMBL3938650 | 0.74 | APP (0.36) | AKR1C3AKR1C4KMT2A | |
| SCHEMBL28090813 | 0.72 | PDE5A (0.42) | PPARGALDH1A1OXER1AKR1C3AKR1C4 | |
| SCHEMBL29197999 | 0.71 | PPARG (0.44) | PPARGFFAR1ALDH1A1MAPTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024140969-A1 | TRICYCLIC COMPOUND, AND PREPARATION METHOD AND USE THEREFOR | 广州市联瑞制药有限公司 | 2024-07-04 | — | — | WO | disclosed |