Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 19/20 | 0.36 |
| ▸ | PRNP | P04156 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22848023 | 1.00 | KRAS (0.36) | KRASPRNPPOLBKMT2ARXFP1 | |
| SCHEMBL31053006 | 0.93 | KRAS (0.32) | KRAS | |
| SCHEMBL28678937 | 0.88 | KDM4E (0.39) | KRASPRNPRXFP1SOS1 | |
| SCHEMBL22848293 | 0.85 | KRAS (0.38) | KRASSOS1 | |
| SCHEMBL22848180 | 0.85 | KRAS (0.38) | KRASSOS1 | |
| SCHEMBL31053011 | 0.85 | KRAS (0.50) | KRASSOS1 | |
| SCHEMBL29238703 | 0.85 | KRAS (0.50) | KRASSOS1 | |
| SCHEMBL28682007 | 0.84 | KRAS (0.39) | KRASSOS1 | |
| SCHEMBL22720513 | 0.83 | KRAS (0.39) | KRASSOS1 | |
| SCHEMBL29486382 | 0.83 | KRAS (0.39) | KRASSOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114008037-B | Heterocyclic compounds as KRAS G12C inhibitors | 广东新契生物医药科技有限公司 | 2024-06-21 | — | — | CN | disclosed |