Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WRN | Q14191 | 1/20 | 0.55 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 3/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25036809 | 1.00 | WRN (0.55) | WRNGPR119ACHEMAPK8MAPT | |
| SCHEMBL31499590 | 0.97 | WRN (0.53) | WRNGPR119ACHEMAPK8MAPT | |
| SCHEMBL30038960 | 0.94 | WRN (0.50) | WRNGPR119ACHEMAPK8MAPT | |
| SCHEMBL30038096 | 0.93 | WRN (0.49) | WRNGPR119MAPTALDH1A1BACE1 | |
| SCHEMBL25035212 | 0.93 | WRN (0.49) | WRNGPR119MAPTALDH1A1BACE1 | |
| SCHEMBL31500029 | 0.93 | WRN (0.47) | WRNGPR119MAPTALDH1A1BACE1 | |
| SCHEMBL31394551 | 0.92 | WRN (0.48) | WRNGPR119ACHEMAPK8MAPT | |
| SCHEMBL31499880 | 0.92 | WRN (0.48) | WRNGPR119ACHEMAPK8MAPT | |
| SCHEMBL31499631 | 0.91 | WRN (0.47) | WRNMAPTBACE1TSHRUSP2 | |
| SCHEMBL30038405 | 0.91 | WRN (0.51) | WRNGPR119ACHEMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025087274-A1 | AZABICYCLO DERIVATIVE AND PREPARATION METHOD THEREFOR, AND USE | 浙江海正药业股份有限公司 | 2025-05-01 | — | — | WO | disclosed |
| CN-119899186-A | Azabicyclo derivative and preparation method and application thereof | 浙江海正药业股份有限公司 | 2025-04-29 | — | — | CN | disclosed |
| WO-2025049746-A1 | COMPOSITIONS COMPRISING WERNER SYNDROME HELICASE INHIBITORS AND METHODS OF USING THE SAME | EIKON THERAPEUTICS, INC. (US) | 2025-03-06 | — | — | WO | disclosed |
| WO-2024220887-A1 | [1,2,4]TRIAZOLO[1,5-A]PYRIMIDINONE WRN INHIBITORS | NIMBUS WADJET, INC. (US) | 2024-10-24 | — | — | WO | disclosed |
| WO-2024155884-A1 | HETEROCYCLIC COMPOUNDS AS WRN INHIBITORS | SYNNOVATION THERAPEUTICS, INC. (US) | 2024-07-25 | — | — | WO | disclosed |