Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Akn-028. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 known ✓ | P36888 | 1/20 | 1.00 |
| ▸ | FGFR2 | P21802 | 1/20 | 1.00 |
| ▸ | ATR | Q13535 | 2/20 | 0.53 |
| ▸ | EGFR | P00533 | 7/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PRKCI | P41743 | 1/20 | 0.44 |
| ▸ | FLT1 | P17948 | 6/20 | 0.43 |
| ▸ | KDR | P35968 | 2/20 | 0.43 |
| ▸ | PRKD1 | Q15139 | 1/20 | 0.41 |
| ▸ | SYK | P43405 | 3/20 | 0.41 |
| ▸ | BUB1 | O43683 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | ULK1 | O75385 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Akn-028 SCHEMBL1642669 | 1.00 | FGFR2 (1.00) | FGFR2FLT3ATREGFRMAPK1 | |
| SCHEMBL1642621 | 0.89 | FGFR2 (0.81) | FGFR2FLT3ATREGFRMAPK1 | |
| SCHEMBL1642585 | 0.88 | FGFR2 (0.78) | FGFR2FLT3ATREGFRMAPK1 | |
| SCHEMBL1641637 | 0.88 | FGFR2 (0.78) | FGFR2FLT3ATREGFRPRKCI | |
| SCHEMBL1643091 | 0.87 | FGFR2 (0.78) | FGFR2FLT3ATREGFRMAPK1 | |
| SCHEMBL1640884 | 0.86 | FGFR2 (0.76) | FGFR2FLT3ATREGFRPRKCI | |
| SCHEMBL1641493 | 0.85 | FGFR2 (0.74) | FGFR2FLT3ATREGFRPRKCI | |
| SCHEMBL1642794 | 0.84 | FGFR2 (0.72) | FGFR2FLT3ATREGFRFLT1 | |
| SCHEMBL1642507 | 0.84 | FGFR2 (0.72) | FGFR2FLT3ATREGFRMAPK1 | |
| SCHEMBL1641464 | 0.83 | FGFR2 (0.71) | FGFR2FLT3ATREGFRPRKCI |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4662319-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | Integrate Bioscience LLC (US) | 2025-12-17 | — | — | EP | disclosed |
| WO-2024168301-A2 | PERSONALIZED CRISPR PROFILING FOR CANCER | FUNCTION ONCOLOGY, INC. (US) | 2024-08-15 | — | — | WO | disclosed |