Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.48 |
| ▸ | SNCA | P37840 | 1/20 | 0.97 |
| ▸ | INSR | P06213 | 8/20 | 0.59 |
| ▸ | MAPT | P10636 | 4/20 | 0.51 |
| ▸ | APP | P05067 | 2/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | NSD2 | O96028 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL31063717 | 0.99 | SNCA (1.00) | SNCAINSRMAPTAPPACHE | |
| Iodide SCHEMBL31063752 | 0.91 | SNCA (0.86) | SNCAINSRMAPTAPPACHE | |
| Iodide SCHEMBL31063768 | 0.90 | SNCA (0.80) | SNCAINSRMAPTAPPACHE | |
| Iodide SCHEMBL31063626 | 0.90 | SNCA (0.80) | SNCAINSRMAPTAPPACHE | |
| Iodide SCHEMBL31063786 | 0.90 | SNCA (0.80) | SNCAINSRMAPTAPPACHE | |
| Iodide SCHEMBL31063710 | 0.88 | SNCA (0.77) | SNCAINSRMAPTAPPACHE | |
| SCHEMBL12333747 | 0.85 | SNCA (0.73) | SNCAINSRMAPTAPPACHE | |
| Iodide SCHEMBL31063743 | 0.84 | SNCA (0.75) | SNCAINSRMAPTAPPACHE | |
| Iodide SCHEMBL31063782 | 0.84 | SNCA (0.75) | SNCAINSRMAPTAPPACHE | |
| Iodide SCHEMBL31063831 | 0.83 | SNCA (0.73) | SNCAINSRMAPTAPPACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024200263-A1 | 2-STYRYLBENZOTHIAZOLE DERIVATIVES AS α-SYNUCLEIN BINDING COMPOUNDS | EBERHARD KARLS UNIVERSITAET TUEBINGEN MEDIZINISCHE FAKULTAET (DE) | 2024-10-03 | — | — | WO | disclosed |
| EP-4438597-A1 | 2-STYRYLBENZOTHIAZOLE DERIVATIVES AS A-SYNUCLEIN BINDING COMPOUNDS | Eberhard Karls Universität Tübingen Medizinische Fakultät (DE) | 2024-10-02 | — | — | EP | disclosed |