SCHEMBL31066529

SCHEMBL31066529

Cc1nc2c(F)cc(-c3nc(Nc4ccc5c(n4)CCN(CCN(C)CCN)C5)ncc3F)cc2n1C(C)C

nearest known ligand 0.88

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CDK4 P11802 20/20 0.88
CDK2 P24941 18/20 0.88
CDK6 Q00534 18/20 0.88
CCNA2 P20248 10/20 0.88
CCND3 P30281 10/20 0.88
CDK1 P06493 9/20 0.88
CDK7 P50613 6/20 0.88
CDK9 P50750 6/20 0.88
CCNB1 P14635 5/20 0.88
CCNE1 P24864 5/20 0.88
CDK5 Q00535 4/20 0.88
CHEK1 O14757 1/20 0.88
CCNT1 O60563 1/20 0.88
JAK2 O60674 1/20 0.88
CHEK2 O96017 1/20 0.88
EGFR P00533 1/20 0.88
RAF1 P04049 1/20 0.88
NTRK1 P04629 1/20 0.88
PDGFRB P09619 1/20 0.88
SRC P12931 1/20 0.88

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL19089443 1.00 CDK4 (0.88) CDK4CDK2CDK6CCNA2CCND3
Hydrochloric Acid SCHEMBL22261808 0.99 CDK4 (0.87) CDK4CDK2CDK6CCNA2CCND3
Hydrochloric Acid SCHEMBL31066337 0.99 CDK4 (0.87) CDK4CDK2CDK6CCNA2CCND3
SCHEMBL19089132 0.94 CDK4 (1.00) CDK4CDK2CDK6CCNA2CCND3
SCHEMBL19089025 0.93 CDK4 (1.00) CDK4CDK2CDK6CCNA2CCND3
SCHEMBL19089098 0.93 CDK4 (0.91) CDK4CDK2CDK6CCNA2CCND3
SCHEMBL19089031 0.93 CDK4 (0.85) CDK4CDK2CDK6CCNA2CCND3
SCHEMBL22280791 0.92 CDK4 (0.89) CDK4CDK2CDK6CCNA2CCND3
Hydrochloric Acid SCHEMBL20548753 0.92 CDK4 (0.90) CDK4CDK2CDK6CCNA2CCND3
SCHEMBL17485310 0.92 CDK4 (1.00) CDK4CDK2CDK6CCNA2CCND3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3398947-B1 NITROGEN-CONTAINING FUSED HETEROCYCLIC COMPOUND, AS WELL AS PREPARATION METHOD, INTERMEDIATE, COMPOSITION AND APPLICATION THEREOF SHANGHAI PHARMACEUTICALS HOLDING CO LTD (CN) 2024-08-28 EP disclosed