Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 8/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 8/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22776108 | 0.75 | NOTUM (0.47) | SMN1; SMN2HTR2ACYP1A2MAPTKDM4E | |
| SCHEMBL15354404 | 0.72 | HTR2A (0.54) | CHEK2SMN1; SMN2HPGDHTR2ASLC6A4 | |
| SCHEMBL4876521 | 0.72 | MAPK13 (0.34) | SMN1; SMN2HPGDLMNALTA4HCYP1A2 | |
| SCHEMBL28896993 | 0.68 | CLK4 (0.44) | SMN1; SMN2HPGDLMNAMAPTKDM4E | |
| SCHEMBL22719935 | 0.67 | KDM4E (0.43) | SMN1; SMN2HPGDHTR2ASLC6A4KCNH2 | |
| SCHEMBL29899213 | 0.67 | CHRNB4 (0.51) | SMN1; SMN2HPGDKCNH2MAPTALDH1A1 | |
| SCHEMBL30594257 | 0.65 | MAOB (0.39) | SMN1; SMN2HPGDLMNAHTR2AMAPT | |
| SCHEMBL22719503 | 0.65 | TEAD1 (0.73) | SMN1; SMN2HPGDLMNATEAD1MAPT | |
| SCHEMBL22719849 | 0.65 | TEAD1 (0.73) | SMN1; SMN2HPGDLMNATEAD1MAPT | |
| SCHEMBL22719501 | 0.65 | TEAD1 (0.73) | SMN1; SMN2HPGDLMNATEAD1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024176130-A1 | TEAD- AND HER2-INHIBITOR COMBINATIONS FOR TREATING CANCER | NOVARTIS AG (CH) | 2024-08-29 | — | — | WO | disclosed |