SCHEMBL31069437

SCHEMBL31069437

CC(C)(C)OC(=O)NCc1ccc2c(c1)nc(Cn1c(=O)n(C3CC3)c3ccc(F)cc31)n2CCCC(F)(F)F

nearest known ligand 0.53

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
CYP3A4 P08684 2/20 0.44
GNRHR P30968 1/20 0.42
GRM2 Q14416 1/20 0.40
CCR3 P51677 1/20 0.37
RORC P51449 1/20 0.36
CYP11B2 P19099 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31069360 0.83 CYP3A4 (0.49) CYP3A4CCR3
SCHEMBL6243686 0.81 CYP3A4 (0.43) CYP3A4GNRHRGRM2RORC
SCHEMBL31069497 0.81 GNRHR (0.47) CYP3A4GNRHRGRM2
SCHEMBL31069458 0.80 CYP3A4 (0.47) CYP3A4CCR3
SCHEMBL3734568 0.80 GRM2 (0.46) CYP3A4GNRHRGRM2
SCHEMBL6245596 0.79 CYP3A4 (0.50) CYP3A4GNRHRGRM2RORC
SCHEMBL7879921 0.79 GNRHR (0.43) CYP3A4GNRHRGRM2
SCHEMBL2878881 0.78 GNRHR (0.37) GNRHR
SCHEMBL6220287 0.77 CYP3A4 (0.41) CYP3A4GNRHRRORC
SCHEMBL6245226 0.77 BCHE (0.42) CYP3A4GNRHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024174953-A1 BENZIMIDAZOLE DERIVATIVE AND MEDICAL USE THEREOF 苏州隆博泰药业有限公司 2024-08-29 WO disclosed