Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR2 | Q92731 | 1/20 | 0.47 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | NAMPT | P43490 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29407578 | 0.88 | ESR2 (0.46) | ESR2NR1H2HDAC1DDB1CRBN | |
| SCHEMBL22993188 | 0.88 | ESR2 (0.46) | ESR2NR1H2HDAC1DDB1CRBN | |
| SCHEMBL12283366 | 0.84 | ESR2 (0.48) | ESR2NR1H2HDAC1DDB1CRBN | |
| SCHEMBL29390606 | 0.84 | ESR2 (0.48) | ESR2NR1H2HDAC1DDB1CRBN | |
| SCHEMBL29554271 | 0.84 | NR1H2 (0.66) | ESR2NR1H2GPR119HDAC1DDB1 | |
| SCHEMBL12006705 | 0.84 | NR1H2 (0.66) | ESR2NR1H2GPR119HDAC1DDB1 | |
| SCHEMBL22993203 | 0.82 | ESR2 (0.46) | ESR2NR1H2GPR119HDAC1DDB1 | |
| SCHEMBL29388532 | 0.82 | ESR2 (0.46) | ESR2NR1H2GPR119HDAC1DDB1 | |
| SCHEMBL8280135 | 0.82 | ESR2 (0.56) | ESR2NR1H2GPR119HDAC1DDB1 | |
| SCHEMBL29835137 | 0.82 | ESR2 (0.56) | ESR2NR1H2GPR119HDAC1DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4665330-A1 | PLASMA KALLIKREIN INHIBITORS | Merck Sharp & Dohme LLC (US) | 2025-12-24 | — | — | EP | disclosed |
| WO-2024173196-A1 | PLASMA KALLIKREIN INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2024-08-22 | — | — | WO | disclosed |