Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 10/20 | 0.61 |
| ▸ | DRD4 | P21917 | 5/20 | 0.61 |
| ▸ | DRD2 | P14416 | 4/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.55 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | HTR2C | P28335 | 5/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 4/20 | 0.53 |
| ▸ | HTR2A | P28223 | 4/20 | 0.53 |
| ▸ | HRH2 | P25021 | 3/20 | 0.53 |
| ▸ | HRH1 | P35367 | 3/20 | 0.53 |
| ▸ | DRD1 | P21728 | 3/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL310790 | 1.00 | HRH4 (0.61) | HRH4DRD4DRD2MEN1LMNA | |
| SCHEMBL301395 | 0.89 | HRH4 (0.59) | HRH4DRD4DRD2MEN1LMNA | |
| SCHEMBL300929 | 0.88 | HRH4 (0.57) | HRH4DRD4DRD2MEN1LMNA | |
| SCHEMBL311113 | 0.87 | HRH4 (0.56) | HRH4DRD4DRD2MEN1LMNA | |
| SCHEMBL311114 | 0.87 | HRH4 (0.56) | HRH4DRD4DRD2MEN1LMNA | |
| SCHEMBL300234 | 0.86 | HRH4 (0.55) | HRH4DRD4DRD2MEN1LMNA | |
| SCHEMBL300235 | 0.86 | HRH4 (0.55) | HRH4DRD4DRD2MEN1LMNA | |
| SCHEMBL311618 | 0.86 | HRH4 (0.55) | HRH4DRD4DRD2MEN1LMNA | |
| SCHEMBL300267 | 0.86 | HRH4 (0.55) | HRH4DRD4DRD2MEN1LMNA | |
| SCHEMBL300295 | 0.86 | HRH4 (0.57) | HRH4DRD4DRD2MEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8093237-B2 | 11-(piperazin-1-yl)dibenzo[b,f][1,4]oxazapine compounds; psychological disorders, sleep disorders; antipsychotic agents that modulate monoaminergic neurotransmitter receptor subtypes; side effect reduction | ARYX THERAPEUTICS, INC. (US) | 2012-01-10 | — | — | US | claimed |