Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 4/20 | 0.53 |
| ▸ | SCD5 | Q86SK9 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | XPO1 | O14980 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3321553 | 0.90 | SCD (0.64) | SCDSCD5 | |
| SCHEMBL13332472 | 0.87 | SCD (0.61) | SCDSCD5ALDH1A1MAPK1MAPT | |
| SCHEMBL13361544 | 0.84 | SCD (0.48) | SCDSCD5 | |
| SCHEMBL3261795 | 0.83 | SCD (0.46) | SCDSCD5ALDH1A1MAPK1HPGD | |
| SCHEMBL3320133 | 0.78 | SCD (0.64) | SCDSCD5ALDH1A1POLBLMNA | |
| SCHEMBL3320435 | 0.77 | SCD (0.74) | SCDSCD5 | |
| SCHEMBL3328862 | 0.76 | SCD (0.63) | SCDSCD5 | |
| SCHEMBL3323795 | 0.75 | SCD (0.60) | SCDSCD5ALDH1A1XPO1POLB | |
| SCHEMBL13332435 | 0.73 | SCD (0.53) | SCDSCD5ALDH1A1MAPK1MAPT | |
| SCHEMBL13361526 | 0.72 | SCD (0.48) | SCDSCD5ALDH1A1XPO1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148878-A1 | NOVEL HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | Merck Frosst Canada Ltd. (CA) | 2010-02-03 | — | — | EP | disclosed |
| WO-2008128335-A1 | NOVEL HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A DELTA-9 DESATURASE | MERCK FROSST CANADA LTD. (CA) | 2008-10-30 | — | — | WO | disclosed |