Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.79 |
| ▸ | MAPT | P10636 | 4/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.79 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.79 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.79 |
| ▸ | LMNA | P02545 | 3/20 | 0.79 |
| ▸ | HTT | P42858 | 2/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.79 |
| ▸ | HPGD | P15428 | 1/20 | 0.79 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.79 |
| ▸ | KDR | P35968 | 11/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.60 |
| ▸ | FLT1 | P17948 | 2/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.58 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | CSF1R | P07333 | 1/20 | 0.58 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.58 |
| ▸ | KIT | P10721 | 1/20 | 0.58 |
| ▸ | FLT4 | P35916 | 1/20 | 0.58 |
| ▸ | GLA | P06280 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3118645 | 0.95 | MEN1 (0.87) | MEN1MAPTKMT2AL3MBTL1RXFP1 | |
| SCHEMBL5666682 | 0.87 | RXFP1 (0.76) | MEN1MAPTKMT2AL3MBTL1RXFP1 | |
| SCHEMBL427615 | 0.86 | KDR (0.84) | MEN1MAPTKMT2AL3MBTL1RXFP1 | |
| Hydrochloric Acid SCHEMBL447740 | 0.85 | KDR (0.83) | MEN1MAPTKMT2AL3MBTL1RXFP1 | |
| SCHEMBL4981375 | 0.82 | RXFP1 (0.84) | MEN1MAPTKMT2AL3MBTL1RXFP1 | |
| Hydrochloric Acid SCHEMBL445155 | 0.80 | KDR (0.79) | MEN1MAPTKMT2AL3MBTL1RXFP1 | |
| SCHEMBL427683 | 0.79 | RXFP1 (0.75) | MEN1MAPTKMT2AL3MBTL1RXFP1 | |
| SCHEMBL3109871 | 0.79 | RXFP1 (0.81) | MEN1MAPTKMT2AL3MBTL1RXFP1 | |
| Hydrochloric Acid SCHEMBL4405252 | 0.78 | RXFP1 (0.80) | MEN1MAPTKMT2AL3MBTL1RXFP1 | |
| SCHEMBL427736 | 0.77 | KDR (0.64) | MEN1MAPTKMT2AL3MBTL1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2168948-A1 | 2-AMINO-NICOTINAMIDE DERIVATIVES AND THEIR USE AS VEGF-RECEPTOR TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2010-03-31 | — | — | EP | disclosed |