Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT2 | P31751 | 3/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
| ▸ | INCENP | Q9NQS7 | 1/20 | 0.35 |
| ▸ | TPX2 | Q9ULW0 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.33 |
| ▸ | PIM2 | Q9P1W9 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3419294 | 0.77 | AKT2 (0.52) | AKT2AKT1CHEK1CHEK2ABL1 | |
| SCHEMBL30582723 | 0.74 | AKT2 (0.48) | AKT2AKT1CHEK1CHEK2ABL1 | |
| SCHEMBL26131947 | 0.74 | AKT2 (0.48) | AKT2AKT1CHEK1CHEK2ABL1 | |
| SCHEMBL3740850 | 0.72 | AKT2 (0.70) | AKT2AKT1CHEK1CHEK2ABL1 | |
| SCHEMBL26953475 | 0.71 | AKT2 (0.50) | AKT2AKT1CHEK1CHEK2ABL1 | |
| SCHEMBL481994 | 0.71 | AKT2 (0.61) | AKT2AKT1CHEK1CHEK2ABL1 | |
| SCHEMBL26172871 | 0.71 | NPC1 (0.41) | CHEK1ABL1AURKAAURKBNPC1 | |
| Hydrochloric Acid SCHEMBL28973063 | 0.70 | AKT2 (0.67) | AKT2AKT1CHEK1CHEK2ABL1 | |
| SCHEMBL22777207 | 0.70 | LRRK2 (0.57) | AKT2AKT1CHEK1ABL1MAPK1 | |
| SCHEMBL30792042 | 0.70 | AKT2 (0.43) | AKT2AKT1CHEK1CHEK2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4676547-A2 | ALPHA-SYNUCLEIN BINDERS AND METHODS OF USE | Merck Sharp & Dohme LLC (US) | 2026-01-14 | — | — | EP | disclosed |
| WO-2024186584-A2 | ALPHA-SYNUCLEIN BINDERS AND METHODS OF USE | MERCK SHARP & DOHME LLC (US) | 2024-09-12 | — | — | WO | disclosed |