⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3108943 | 0.79 | — | — | |
| SCHEMBL17656352 | 0.79 | — | — | |
| SCHEMBL7346515 | 0.76 | — | — | |
| SCHEMBL2805863 | 0.74 | — | — | |
| SCHEMBL9130393 | 0.72 | — | — | |
| SCHEMBL10011291 | 0.72 | CYP2C19 (0.44) | — | |
| SCHEMBL1466765 | 0.70 | GAA (0.44) | — | |
| SCHEMBL12820432 | 0.70 | CPT2 (0.48) | — | |
| SCHEMBL13469289 | 0.70 | TSHR (0.33) | — | |
| SCHEMBL16269785 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 35 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12503553-B2 | Biodegradable drug-polymer conjugate | POLYACTIVA PTY LTD (AU) | 2025-12-23 | — | — | US | disclosed |
| US-12492170-B2 | Tetrahydro-1H-benzazepine compound as potassium channel modulator, preparation method and use thereof | SHANGHAI ZHIMENG BIOPHARMA, INC. (CN) | 2025-12-09 | — | — | US | disclosed |
| US-20240247106-A1 | BIODEGRADABLE DRUG-POLYMER CONJUGATE | POLYACTIVA PTY LTD (AU) | 2024-07-25 | — | — | US | disclosed |
| EP-3978478-B1 | TETRAHYDRO-1H-BENZAZEPINE COMPOUND AS POTASSIUM CHANNEL MODULATOR, PREPARATION METHOD AND USE THEREOF | SHANGHAI ZHIMENG BIOPHARMA INC (CN) | 2024-02-14 | — | — | EP | disclosed |
| US-11787906-B2 | Biodegradable drug-polymer conjugate | POLYACTIVA PTY LTD (AU) | 2023-10-17 | — | — | US | disclosed |
| US-20220227713-A1 | TETRAHYDRO-1H-BENZAZEPINE COMPOUND AS POTASSIUM CHANNEL MODULATOR, PREPARATION METHOD AND USE THEREOF | SHANGHAI ZHIMENG BIOPHARMA, INC. (CN) | 2022-07-21 | — | — | US | disclosed |
| EP-3978478-A1 | TETRAHYDRO-1H-BENZAZEPINE COMPOUND AS POTASSIUM CHANNEL MODULATOR, PREPARATION METHOD AND USE THEREOF | Shanghai Zhimeng Biopharma, Inc. (CN) | 2022-04-06 | — | — | EP | disclosed |
| CN-113767091-A | tetrahydro-1H-benzazepine compounds as potassium channel modulators, and preparation and application thereof | 上海挚盟医药科技有限公司 | 2021-12-07 | — | — | CN | disclosed |
| CN-112010808-B | tetrahydro-1H-benzazepine compounds as potassium channel modulators, and preparation and application thereof | 上海挚盟医药科技有限公司 | 2021-11-30 | — | — | CN | disclosed |
| WO-2020238917-A1 | TETRAHYDRO-1H-BENZAZEPINE COMPOUND AS POTASSIUM CHANNEL MODULATOR, PREPARATION METHOD AND USE THEREOF | 上海挚盟医药科技有限公司 | 2020-12-03 | — | — | WO | disclosed |
| US-20130310378-A1 | 4-(4-PYRIDINYL)-BENZAMIDES AND THEIR USE AS ROCK ACTIVITY MODULATORS | ABBVIE INC. (US) | 2013-11-21 | — | — | US | disclosed |
| US-8445686-B2 | 4-(4-pyridinyl)-benzamides and their use as rock activity modulators | ABBVIE INC. (US) | 2013-05-21 | — | — | US | disclosed |
| US-20100273828-A1 | 4-(4-PYRIDINYL)-BENZAMIDES AND THEIR USE AS ROCK ACTIVITY MODULATORS | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2010-10-28 | — | — | US | disclosed |
| EP-2193119-A1 | 4-(4-PYRIDINYL)-BENZAMIDES AND THEIR USE AS ROCK ACTIVITY MODULATORS | Abbott GmbH & Co. KG (DE) | 2010-06-09 | — | — | EP | disclosed |
| WO-2009027392-A1 | 4-(4-PYRIDINYL)-BENZAMIDES AND THEIR USE AS ROCK ACTIVITY MODULATORS | ABBOTT GMBH & CO. KG (DE) | 2009-03-05 | — | — | WO | disclosed |
| US-5200169-A | Vinyl substituted radiohalogen conjugates for protein labeling | NEORX CORPORATION (US) | 1993-04-06 | — | — | US | disclosed |
| US-4876081-A | Vinyl substituted radiohalogen and methods of use conjugates | NEORX CORPORATION (US) | 1989-10-24 | — | — | US | disclosed |
| US-4870188-A | Vinyl substituted radiohalogen conjugates for protein labeling | NEORX CORPORATION (US) | 1989-09-26 | — | — | US | disclosed |
| CN-1030748-A | The vinyl conjugate that the radiohalogen of labelled protein replaces | NEORX CORP (US) | 1989-02-01 | — | — | CN | disclosed |
| EP-0289187-A2 | Vinyl substituted radiohalogen conjugates for protein labeling | NEORX CORPORATION (US) | 1988-11-02 | — | — | EP | disclosed |