Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACVR1 | Q04771 | 7/20 | 0.61 |
| ▸ | PAK4 | O96013 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 2/20 | 0.45 |
| ▸ | PDE5A | O76074 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | WDR5 | P61964 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20589975 | 1.00 | ACVR1 (0.61) | ACVR1PAK4MAPTKDM4EMEN1 | |
| SCHEMBL25213054 | 0.84 | ACVR1 (0.46) | ACVR1PAK4MAPTKDM4EMEN1 | |
| SCHEMBL20589165 | 0.83 | ACVR1 (0.61) | ACVR1APPPOLB | |
| SCHEMBL30095810 | 0.83 | ACVR1 (0.61) | ACVR1APPPOLB | |
| SCHEMBL31095303 | 0.83 | JAK2 (0.56) | ACVR1PAK4MAPTKDM4EMEN1 | |
| SCHEMBL2188370 | 0.83 | JAK2 (0.56) | ACVR1PAK4MAPTKDM4EMEN1 | |
| SCHEMBL25195068 | 0.82 | ACVR1 (0.65) | ACVR1PAK4JAK2WDR5 | |
| SCHEMBL25212165 | 0.82 | ACVR1 (0.62) | ACVR1PAK4WDR5 | |
| SCHEMBL25201183 | 0.79 | ACVR1 (0.46) | ACVR1PAK4MAPK1WDR5POLB | |
| SCHEMBL25201204 | 0.79 | ACVR1 (0.47) | ACVR1PAK4MAPTSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119060060-A | Imidazole-containing ALK2 kinase inhibitors | 拜奥克里斯特制药公司 | 2024-12-03 | — | — | CN | disclosed |
| CN-110913855-B | Imidazole-containing ALK2 kinase inhibitors | 拜奥克里斯特制药公司 | 2024-09-03 | — | — | CN | disclosed |