Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CFTR | P13569 | 11/20 | 0.49 |
| ▸ | SRC | P12931 | 3/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 3/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | TEK | Q02763 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | ABL2 | P42684 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20162786 | 1.00 | CFTR (0.49) | CFTRSRCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL30538111 | 0.89 | CFTR (0.62) | CFTRSRC | |
| SCHEMBL20162756 | 0.89 | CFTR (0.62) | CFTRSRC | |
| SCHEMBL30037497 | 0.89 | CFTR (0.62) | CFTRSRC | |
| SCHEMBL20162754 | 0.89 | CFTR (0.62) | CFTRSRC | |
| SCHEMBL20162750 | 0.87 | CFTR (0.47) | CFTRSRCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL20162752 | 0.87 | CFTR (0.47) | CFTRSRCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL30538084 | 0.87 | CFTR (0.47) | CFTRSRCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL30036843 | 0.87 | CFTR (0.47) | CFTRSRCPIK3CDPIK3CAPIK3CB | |
| SCHEMBL30538110 | 0.87 | CFTR (0.49) | CFTRSRCPIK3CDPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4424311-A2 | PYRROLOPYRIMIDINES AS CFTR POTENTIATORS | Cystic Fibrosis Foundation (US) | 2024-09-04 | — | — | EP | disclosed |