Known targets — ChEMBL curated mechanism
rplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Chlortetracycline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.71 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.71 |
| ▸ | GAA | P10253 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 3/20 | 0.71 |
| ▸ | POLB | P06746 | 3/20 | 0.71 |
| ▸ | THRB | P10828 | 2/20 | 0.71 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.71 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.71 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.71 |
| ▸ | PDE4A | P27815 | 1/20 | 0.71 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 10/20 | 0.70 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 7/20 | 0.70 |
| ▸ | USP2 | O75604 | 5/20 | 0.70 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chlortetracycline SCHEMBL19787489 | 1.00 | MAPT (0.71) | MAPTHSD17B10GAALMNAPOLB | |
| Chlortetracycline SCHEMBL27323552 | 1.00 | MAPT (0.71) | MAPTHSD17B10GAALMNAPOLB | |
| Chlortetracycline SCHEMBL5503038 | 1.00 | MAPT (0.71) | MAPTHSD17B10GAALMNAPOLB | |
| Chlortetracycline SCHEMBL10901448 | 1.00 | MAPT (0.71) | MAPTHSD17B10GAALMNAPOLB | |
| Chlortetracycline SCHEMBL12356689 | 1.00 | MAPT (0.71) | MAPTHSD17B10GAALMNAPOLB | |
| Chlortetracycline SCHEMBL13782583 | 1.00 | MAPT (0.71) | MAPTHSD17B10GAALMNAPOLB | |
| Chlortetracycline SCHEMBL13782533 | 1.00 | MAPT (0.71) | MAPTHSD17B10GAALMNAPOLB | |
| Chlortetracycline SCHEMBL16726392 | 1.00 | MAPT (0.71) | MAPTHSD17B10GAALMNAPOLB | |
| Chlortetracycline SCHEMBL20952683 | 1.00 | MAPT (0.71) | MAPTHSD17B10GAALMNAPOLB | |
| Chlortetracycline SCHEMBL3111 | 1.00 | MAPT (0.71) | MAPTHSD17B10GAALMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 30534 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12636293-B2 | Methods of treating charcot-marie-tooth disease | CMTX BIOTECH INC. (US) | 2026-05-26 | — | — | US | claimed |
| WO-2026105164-A1 | NON-AQUEOUS LIQUID FORMULATIONS OF TETRACYCLINE ANTIBIOTICS | ETICO LIFESCIENCES PRIVATE LIMITED (IN) | 2026-05-21 | — | — | WO | claimed |
| US-20260139860-A1 | PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS | CENTRE FOR DIGESTIVE DISEASES (AU) | 2026-05-21 | — | — | US | claimed |
| WO-2026107279-A1 | METHOD FOR ASSESSING VIABILITY OF MICROBIAL STRAINS | Kanvas Biosciences, Inc. (US) | 2026-05-21 | — | — | WO | claimed |
| EP-4007582-B1 | ANTIBIOTICS IN COMBINATION WITH PHOTODYNAMIC THERAPY FOR USE IN A METHOD OF ENHANCING THE ANTIMICROBIAL ACTION OF SYSTEMICALLY ADMINISTERED ANTIBIOTICS | KOITE HEALTH OY (FI) | 2026-05-20 | — | — | EP | claimed |
| CN-122057521-A | LaFeO3@FeIn2S4 photocatalytic material with core-shell structure, preparation method thereof and application thereof in photo-induced persulfate oxidative degradation of tetracycline antibiotics | 中国科学院青海盐湖研究所 | 2026-05-19 | — | — | CN | claimed |
| CN-116083472-B | Recombinant vector, recombinant strain, kit, application of recombinant vector and recombinant strain and method for producing aureomycin | 金河生物科技股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122004360-A | Natural plant feed raw material capable of replacing aureomycin and preparation method thereof | 山西朗新生物科技有限公司 | 2026-05-12 | — | — | CN | claimed |
| WO-2026090539-A1 | METHODS OF PREVENTING OR TREATING VESICANT-INDUCED INJURY | CMTX BIOTECH INC. (US) | 2026-04-30 | — | — | WO | claimed |
| US-20260108619-A1 | CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS | HANGZHOU DAC BIOTECH CO., LTD. (CN) | 2026-04-23 | — | — | US | claimed |
| US-4186184-A | Selective administration of drug with ocular therapeutic system | ALZA CORPORATION (US) | 1980-01-29 | — | — | US | claimed |
| US-4126680-A | TETRACYCLINE ANTIBIOTIC COMPOSITIONS | PFIZER INC. (US) | 1978-11-21 | — | — | US | claimed |
| US-4081527-A | Chlortetracycline compositions | PFIZER INC. (US) | 1978-03-28 | — | — | US | claimed |
| US-4038388-A | A TETRACYCLINE AND A CHLORINATED 8-HYDROXYQUINOLINE, SYNERGISTIC | PATERSON ZOCHONIS & COMPANY LIMITED (EN) | 1977-07-26 | — | — | US | claimed |
| US-4014335-A | Ocular drug delivery device | ALZA CORPORATION (US) | 1977-03-29 | — | — | US | claimed |
| US-4011313-A | ANTIBIOTICS, POLYOXYALKYLENE GLYCOL VEHICLE | SYNTEX (U.S.A.) INC. (US) | 1977-03-08 | — | — | US | claimed |
| US-4011312-A | PROLONGED RELEASE DRUG FORM FOR THE TREATMENT OF BOVINE MASTITIS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1977-03-08 | — | — | US | claimed |
| US-3996386-A | Method for preventing microbial surface deterioration of foods and feeds | MALKKI YRJO | 1976-12-07 | — | — | US | claimed |
| US-3966922-A | TETRACYCLINE, VITAMIN B(2), VANILLIN | TAKEDA CHEMICAL INDUSTRIES, LTD. (JA) | 1976-06-29 | — | — | US | claimed |
| US-3962414-A | Structured bioerodible drug delivery device | ALZA CORPORATION (US) | 1976-06-08 | — | — | US | claimed |