SCHEMBL31113635

SCHEMBL31113635

COc1cnc2c(-c3nc4cc(F)c(OC[C@@H](C)OC(=O)Nc5cnc(OC[C@H](C)O)nc5)nc4s3)cc(C)cc2n1

nearest known ligand 0.63

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
F2RL3 Q96RI0 20/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21395577 1.00 F2RL3 (0.63) F2RL3
SCHEMBL21395761 1.00 F2RL3 (0.63) F2RL3
SCHEMBL31113726 1.00 F2RL3 (0.63) F2RL3
SCHEMBL19783790 0.95 F2RL3 (0.57) F2RL3
SCHEMBL31113716 0.94 F2RL3 (0.56) F2RL3
SCHEMBL21396124 0.94 F2RL3 (0.56) F2RL3
SCHEMBL31113702 0.93 F2RL3 (0.61) F2RL3
SCHEMBL21396146 0.93 F2RL3 (0.61) F2RL3
SCHEMBL31113575 0.92 F2RL3 (0.57) F2RL3
SCHEMBL19782708 0.92 F2RL3 (0.57) F2RL3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12060347-B2 Bicyclic heteroaryl substituted compounds BRISTOL-MYERS SQUIBB COMPANY (US) 2024-08-13 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12060347-B2 Bicyclic heteroaryl substituted compounds F2, F2RL3, F12 F2RL3 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.