Sugi Predict

Sugi Predict / Compounds / SCHEMBL31123764

SCHEMBL31123764

SCHEMBL31123764

CC(C)(C)[Si](OC[C@@]1(C)O[C@@H](n2ccc3c(Cl)ncnc32)[C@H](O)[C@]1(C)O)(c1ccccc1)c1ccccc1

nearest known ligand 0.40

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ PRMT5 O14744 19/20 0.40
▸ WDR77 Q9BQA1 18/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30004392 0.86 PRMT5 (0.34) PRMT5WDR77
SCHEMBL23535905 0.76 PRMT5 (0.37) PRMT5WDR77
SCHEMBL31123759 0.76 PRMT5 (0.37) PRMT5WDR77
SCHEMBL21061581 0.76 PRMT5 (0.34) PRMT5WDR77
SCHEMBL21685924 0.75 PRMT5 (0.32) PRMT5WDR77
SCHEMBL21683387 0.75 PRMT5 (0.32) PRMT5WDR77
SCHEMBL21684292 0.74 PRMT5 (0.32) PRMT5WDR77
SCHEMBL31123743 0.74 PRMT5 (0.32) PRMT5WDR77
SCHEMBL31123795 0.74 PRMT5 (0.32) PRMT5WDR77
SCHEMBL21683373 0.74 PRMT5 (0.35) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112805006-B PRMT5 inhibitors 默沙东有限责任公司 2024-09-24 — — CN disclosed