Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EZH2 | Q15910 | 20/20 | 0.81 |
| ▸ | BRD4 | O60885 | 3/20 | 0.62 |
| ▸ | EED | O75530 | 3/20 | 0.56 |
| ▸ | RBBP4 | Q09028 | 3/20 | 0.56 |
| ▸ | SUZ12 | Q15022 | 3/20 | 0.56 |
| ▸ | AEBP2 | Q6ZN18 | 3/20 | 0.56 |
| ▸ | BRD2 | P25440 | 1/20 | 0.54 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.54 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.54 |
| ▸ | EZH1 | Q92800 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31124663 | 0.93 | EZH2 (0.84) | EZH2BRD4EEDRBBP4SUZ12 | |
| SCHEMBL2594888 | 0.89 | EZH2 (1.00) | EZH2BRD4EEDRBBP4SUZ12 | |
| SCHEMBL31124661 | 0.88 | EZH2 (0.82) | EZH2BRD4EEDRBBP4SUZ12 | |
| SCHEMBL28795469 | 0.80 | EZH2 (0.64) | EZH2BRD4EEDRBBP4SUZ12 | |
| SCHEMBL30367815 | 0.79 | EZH2 (0.79) | EZH2BRD4 | |
| SCHEMBL12684416 | 0.78 | EZH2 (1.00) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL30122893 | 0.78 | EZH2 (1.00) | EZH2EEDRBBP4SUZ12AEBP2 | |
| SCHEMBL18863744 | 0.78 | EZH2 (0.78) | EZH2BRD4EEDRBBP4SUZ12 | |
| SCHEMBL28795581 | 0.78 | EZH2 (1.00) | EZH2BRD4BRD2BRD3BRDT | |
| SCHEMBL2595007 | 0.77 | EZH2 (0.74) | EZH2EEDRBBP4SUZ12AEBP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118702679-B | Compound with EZH2/BRD4 double-target activity, pharmaceutical composition, and preparation method and application thereof | 四川大学华西医院 | 2024-10-29 | — | — | CN | disclosed |
| CN-118702679-A | Compound with EZH2/BRD4 double-target activity, pharmaceutical composition, and preparation method and application thereof | 四川大学华西医院 | 2024-09-27 | — | — | CN | disclosed |