Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 7/20 | 0.45 |
| ▸ | CRBN | Q96SW2 | 7/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.37 |
| ▸ | WNT3A | P56704 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26848888 | 0.93 | DDB1 (0.43) | DDB1CRBNPDK2MAPTLMNA | |
| SCHEMBL30688281 | 0.93 | DDB1 (0.43) | DDB1CRBNPDK2MAPTLMNA | |
| SCHEMBL27168084 | 0.84 | DDB1 (0.50) | DDB1CRBNMAPTNAMPTGPR119 | |
| SCHEMBL23538438 | 0.82 | DDB1 (0.57) | DDB1CRBNPDK2MAPTLMNA | |
| SCHEMBL27167732 | 0.81 | NAMPT (0.43) | NAMPTWNT3A | |
| SCHEMBL29930574 | 0.80 | IDO1 (0.44) | DDB1CRBNKITGPR119 | |
| SCHEMBL27031245 | 0.80 | IDO1 (0.44) | DDB1CRBNKITGPR119 | |
| SCHEMBL22119507 | 0.80 | DDB1 (0.59) | DDB1CRBNPDK2MAPTLMNA | |
| SCHEMBL30952388 | 0.80 | DDB1 (0.50) | DDB1CRBNPDK2MAPTLMNA | |
| SCHEMBL31134437 | 0.79 | CRBN (0.41) | DDB1CRBNMAPTHTTCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4688149-A1 | IRAK4 PROTACS | Astrazeneca AB (SE) | 2026-02-11 | — | — | EP | disclosed |
| US-20250197411-A1 | IRAK4 PROTACS | ASTRAZENECA AB (SE) | 2025-06-19 | — | — | US | disclosed |
| WO-2025125575-A1 | IRAK4 PROTACS | ASTRAZENECA AB (SE) | 2025-06-19 | — | — | WO | disclosed |
| US-20240374588-A1 | IRAK4 PROTACS | ASTRAZENECA AB (SE) | 2024-11-14 | — | — | US | disclosed |
| WO-2024209044-A1 | IRAK4 PROTACS | ASTRAZENECA AB (SE) | 2024-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250197411-A1 | IRAK4 PROTACS | IRAK4, IRAK2, IRAK3 | DDB1 750/4885CRBN 94/4885PDK2 1698/4885 |
| US-20240374588-A1 | IRAK4 PROTACS | IRAK4, IRAK2, IRAK3 | DDB1 728/4885CRBN 99/4885PDK2 1636/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.