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SCHEMBL31134606

SCHEMBL31134606

Cn1c(=O)n(C2CCC(=O)NC2=O)c2ccc(N3CCN(C4CCN(C(=O)OC(C)(C)C)CC4)CC3)cc21.Cn1c(=O)n(C2CCC(=O)NC2=O)c2ccc(N3CCN(C4CCNCC4)CC3)cc21

nearest known ligand 0.46

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ DDB1 Q16531 13/20 0.46
▸ CRBN Q96SW2 13/20 0.46
▸ PIK3CA P42336 1/20 0.39
▸ MTOR P42345 1/20 0.39
▸ PRKDC P78527 1/20 0.39
▸ GPR119 Q8TDV5 3/20 0.38
▸ OPRM1 P35372 1/20 0.38
▸ OPRD1 P41143 1/20 0.38
▸ OGFRL1 Q5TC84 1/20 0.38
▸ KHK P50053 1/20 0.37
▸ EGFR P00533 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26101785 0.97 DDB1 (0.49) DDB1CRBNPIK3CAMTORPRKDC
SCHEMBL26098702 0.96 DDB1 (0.48) DDB1CRBNPIK3CAMTORPRKDC
SCHEMBL26100959 0.94 DDB1 (0.46) DDB1CRBNPIK3CAMTORPRKDC
SCHEMBL26102384 0.94 DDB1 (0.49) DDB1CRBNPIK3CAMTORPRKDC
SCHEMBL24480478 0.92 DDB1 (0.47) DDB1CRBNGPR119
SCHEMBL29578984 0.92 DDB1 (0.47) DDB1CRBNGPR119
SCHEMBL26099452 0.91 CRBN (0.47) DDB1CRBNPIK3CAMTORPRKDC
SCHEMBL30768650 0.91 DDB1 (0.55) DDB1CRBNGPR119
SCHEMBL22835971 0.91 DDB1 (0.55) DDB1CRBNGPR119
SCHEMBL30768477 0.91 DDB1 (0.55) DDB1CRBNGPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4688149-A1 IRAK4 PROTACS Astrazeneca AB (SE) 2026-02-11 — — EP disclosed
WO-2024209044-A1 IRAK4 PROTACS ASTRAZENECA AB (SE) 2024-10-10 — — WO disclosed
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