SCHEMBL31158014

SCHEMBL31158014

CC(C)(C)OC(=O)N1CC=C(c2ccc3c(c2)CN(C2CCC(=O)NC2=O)C3=O)C(F)(F)C1

nearest known ligand 0.50

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 13/20 0.50
▸ CSNK1A1 P48729 4/20 0.48
▸ GSPT1 P15170 2/20 0.48
▸ SALL4 Q9UJQ4 1/20 0.48
▸ IKZF3 Q9UKT9 1/20 0.48
▸ IKZF1 Q13422 1/20 0.46
▸ DDB1 Q16531 2/20 0.45
▸ IKZF2 Q9UKS7 6/20 0.44
▸ CYP2C19 P33261 1/20 0.43
▸ KCNH2 Q12809 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21360441 0.91 CRBN (0.51) CRBNCSNK1A1GSPT1SALL4IKZF3
SCHEMBL31091736 0.86 CRBN (0.53) CRBNCSNK1A1GSPT1SALL4IKZF3
SCHEMBL21340251 0.86 IKZF1 (0.55) CRBNCSNK1A1GSPT1SALL4IKZF3
SCHEMBL20046073 0.85 IKZF1 (0.60) CRBNCSNK1A1GSPT1SALL4IKZF3
SCHEMBL29641009 0.85 IKZF1 (0.60) CRBNCSNK1A1GSPT1SALL4IKZF3
SCHEMBL20920016 0.83 IKZF1 (0.57) CRBNCSNK1A1GSPT1SALL4IKZF3
SCHEMBL21340246 0.83 CRBN (0.51) CRBNCSNK1A1GSPT1SALL4IKZF3
SCHEMBL25036239 0.79 DDB1 (0.46) CRBNDDB1
SCHEMBL31736599 0.79 CRBN (0.56) CRBNCSNK1A1GSPT1SALL4IKZF3
SCHEMBL21340263 0.79 IKZF1 (0.53) CRBNCSNK1A1GSPT1SALL4IKZF3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025245178-A1 PAK4, CSTF2, OR CSTF2T PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS INNOVO THERAPEUTICS, INC. (US) 2025-11-27 — — WO disclosed
WO-2024233838-A1 METHODS AND COMPOSITIONS FOR TARGETED PROTEIN DEGRADATION RANOK THERAPEUTICS (HANGZHOU) CO. LTD. (CN) 2024-11-14 — — WO disclosed
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