Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HASPIN | Q8TF76 | 10/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | PLK1 | P53350 | 1/20 | 0.45 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.45 |
| ▸ | PLK2 | Q9NYY3 | 1/20 | 0.45 |
| ▸ | CLK1 | P49759 | 1/20 | 0.45 |
| ▸ | ERN1 | O75460 | 1/20 | 0.38 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GALK1 | P51570 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | SLC22A12 | Q96S37 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1982994 | 0.88 | HASPIN (0.51) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL2005696 | 0.85 | HASPIN (0.48) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL1982292 | 0.78 | TSHR (0.60) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL18935881 | 0.78 | HASPIN (0.54) | HASPINGSK3BDAPK3PLK1PLK3 | |
| Bromide SCHEMBL16238937 | 0.77 | HASPIN (0.52) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL3609606 | 0.76 | HASPIN (0.56) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL14423247 | 0.75 | HASPIN (0.54) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL2502319 | 0.75 | HASPIN (0.54) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL3589139 | 0.75 | HASPIN (0.54) | HASPINGSK3BDAPK3PLK1PLK3 | |
| SCHEMBL568019 | 0.75 | HASPIN (0.54) | HASPINGSK3BDAPK3PLK1PLK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250066318-A1 | HETEROCYCLIC COMPOUNDS AS DYRK1A INHIBITORS | PROTHENA BIOSCIENCES INC | 2025-02-27 | — | — | US | disclosed |
| CN-118843626-A | Heterocyclic compounds as DYRK1A inhibitors | 普罗塞纳生物科学有限公司 | 2024-10-25 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250066318-A1 | HETEROCYCLIC COMPOUNDS AS DYRK1A INHIBITORS | DYRK1A, DYRK2, DYRK1B | HASPIN 1013/4885GSK3B 121/4885DAPK3 73/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.