Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB1 | P23443 | 5/20 | 0.59 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.59 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.59 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.59 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.59 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.59 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.59 |
| ▸ | RPS6KA6 | Q9UK32 | 2/20 | 0.59 |
| ▸ | AKT2 | P31751 | 2/20 | 0.51 |
| ▸ | PAK1 | Q13153 | 6/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | KIT | P10721 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL311202 | 0.99 | RPS6KB1 (0.61) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Hydrochloric Acid SCHEMBL15732558 | 0.83 | RPS6KB1 (0.69) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Hydrochloric Acid SCHEMBL15732557 | 0.83 | RPS6KB1 (0.69) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Hydrochloric Acid SCHEMBL15732443 | 0.82 | RPS6KB1 (0.73) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Hydrochloric Acid SCHEMBL15732641 | 0.79 | RPS6KB1 (0.74) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Hydrochloric Acid SCHEMBL15732522 | 0.79 | RPS6KB1 (0.74) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Hydrochloric Acid SCHEMBL15732695 | 0.73 | RPS6KB1 (0.78) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Hydrochloric Acid SCHEMBL15732523 | 0.72 | RPS6KB1 (0.52) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| Hydrochloric Acid SCHEMBL15732524 | 0.72 | RPS6KB1 (0.57) | RPS6KB1RPS6KA5RPS6KA4RPS6KA3RPS6KA2 | |
| SCHEMBL1003794 | 0.69 | AKT2 (1.00) | RPS6KB1AKT2PAK1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2148880-B1 | P70 S6 KINASE INHIBITORS | LILLY CO ELI (US) | 2014-05-28 | — | — | EP | disclosed |
| US-20120071490-A1 | P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY (US) | 2012-03-22 | — | — | US | disclosed |
| US-8093383-B2 | P70 S6 kinase inhibitors | ELI LILLY AND COMPANY (US) | 2012-01-10 | — | — | US | disclosed |
| US-20090163714-A1 | P70 S6 KINASE INHIBITORS | ELI LILLY AND COMPANY | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163714-A1 | P70 S6 KINASE INHIBITORS | RPS6KA6, RPS6KA1, RPS6KA2 | RPS6KB1 6/4885RPS6KA5 5/4885RPS6KA4 8/4885 |
| US-20120071490-A1 | P70 S6 KINASE INHIBITORS | RPS6KA6, RPS6KA1, RPS6KA2 | RPS6KB1 6/4885RPS6KA5 5/4885RPS6KA4 8/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.