Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.36 |
| ▸ | ALDH1A3 | P47895 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | RXRA | P19793 | 1/20 | 0.35 |
| ▸ | RXRB | P28702 | 1/20 | 0.35 |
| ▸ | RXRG | P48443 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.35 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4004223 | 0.83 | SMN1; SMN2 (0.39) | NOTUMSMN1; SMN2ALOX5L3MBTL1ALDH1A1 | |
| SCHEMBL28745892 | 0.81 | SMN1; SMN2 (0.38) | NOTUMSMN1; SMN2ALOX5L3MBTL1ALDH1A1 | |
| SCHEMBL8276444 | 0.74 | NOTUM (0.50) | NOTUMALOX5CNR2HTR2CHTR2B | |
| SCHEMBL29522795 | 0.73 | SMN1; SMN2 (0.53) | NOTUMSMN1; SMN2L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL94509 | 0.73 | SMN1; SMN2 (0.53) | NOTUMSMN1; SMN2L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL24316034 | 0.73 | NOTUM (0.49) | NOTUMALOX5CNR2HTR2CHTR2B | |
| SCHEMBL3928330 | 0.71 | SMN1; SMN2 (0.44) | NOTUMSMN1; SMN2L3MBTL1ALDH1A1KDM4E | |
| SCHEMBL27570415 | 0.71 | SMN1; SMN2 (0.51) | NOTUMSMN1; SMN2L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL22312090 | 0.71 | NOTUM (0.84) | NOTUMCNR2ALDH1A1DRD2DRD4 | |
| SCHEMBL27329801 | 0.71 | NOTUM (0.47) | NOTUMALOX5CNR2L3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118852123-A | Novel heterocyclic compounds as Pol theta inhibitors for the treatment and prevention of cancer and pharmaceutical compositions containing the same | 株式会社大熊制药 | 2024-10-29 | — | — | CN | disclosed |