Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.59 |
| ▸ | MAPT | P10636 | 5/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | PKM | P14618 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.56 |
| ▸ | PPARG | P37231 | 7/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.48 |
| ▸ | RARG | P13631 | 1/20 | 0.48 |
| ▸ | RXRA | P19793 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.47 |
| ▸ | GMNN | O75496 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7920967 | 0.87 | KMT2A (0.60) | KMT2AMAPTALDH1A1KDM4EPKM | |
| SCHEMBL7914462 | 0.86 | PPARG (0.58) | KMT2AMAPTALDH1A1KDM4EPKM | |
| SCHEMBL3117214 | 0.85 | KMT2A (0.59) | KMT2AMAPTALDH1A1KDM4EPKM | |
| SCHEMBL5374848 | 0.83 | PPARG (0.61) | KMT2AMAPTALDH1A1KDM4EPKM | |
| SCHEMBL4622907 | 0.83 | KMT2A (0.57) | KMT2AMAPTALDH1A1KDM4EPKM | |
| SCHEMBL5381839 | 0.83 | PPARG (0.58) | KMT2AMAPTALDH1A1KDM4EPKM | |
| SCHEMBL1201631 | 0.82 | MAPT (0.66) | KMT2AMAPTALDH1A1KDM4EPKM | |
| SCHEMBL13674890 | 0.81 | KMT2A (0.58) | KMT2AMAPTALDH1A1KDM4EPKM | |
| SCHEMBL3127846 | 0.80 | KMT2A (0.57) | KMT2AMAPTALDH1A1KDM4EPKM | |
| SCHEMBL7822770 | 0.80 | PPARG (0.55) | KMT2AMAPTALDH1A1KDM4EPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010013141-A2 | SUBSTANTIALLY PURE ROSIGLITAZONE HYDROGEN SULFATE | ACTAVIS GROUP PTC EHF (IS) | 2010-02-04 | — | — | WO | claimed |
| WO-2010013141-A2 | SUBSTANTIALLY PURE ROSIGLITAZONE HYDROGEN SULFATE | ACTAVIS GROUP PTC EHF (IS) | 2010-02-04 | — | — | WO | disclosed |
| WO-2010013141-A2 | SUBSTANTIALLY PURE ROSIGLITAZONE HYDROGEN SULFATE | ACTAVIS GROUP PTC EHF (IS) | 2010-02-04 | — | — | WO | disclosed |