Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT7 | O95251 | 4/20 | 0.47 |
| ▸ | KAT6A | Q92794 | 4/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 5/20 | 0.47 |
| ▸ | KAT6B | Q8WYB5 | 1/20 | 0.46 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.46 |
| ▸ | KAT8 | Q9H7Z6 | 1/20 | 0.46 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | PTGES | O14684 | 1/20 | 0.44 |
| ▸ | XPO1 | O14980 | 1/20 | 0.44 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31172714 | 0.91 | KAT7 (0.52) | KAT7KAT6AKAT6BKAT5KAT8 | |
| SCHEMBL31516592 | 0.90 | KAT7 (0.53) | KAT7KAT6ACYSLTR2CYSLTR1KAT6B | |
| SCHEMBL31516704 | 0.87 | KAT7 (0.49) | KAT7KAT6AKAT6B | |
| SCHEMBL31516617 | 0.84 | KAT7 (0.44) | KAT7KAT6ACYSLTR1KAT6BKAT5 | |
| SCHEMBL31516759 | 0.83 | KAT7 (0.43) | KAT7KAT6AKAT6BKAT5KAT8 | |
| SCHEMBL31516718 | 0.83 | KAT7 (0.51) | KAT7KAT6AKAT6BKAT5KAT8 | |
| SCHEMBL31516662 | 0.83 | KAT7 (0.54) | KAT7KAT6ACYSLTR2CYSLTR1KAT6B | |
| SCHEMBL31516861 | 0.83 | KAT7 (0.47) | KAT7KAT6AKAT6BKAT5KAT8 | |
| SCHEMBL31172530 | 0.83 | KAT7 (0.55) | KAT7KAT6ACYSLTR2CYSLTR1KAT6B | |
| SCHEMBL31172604 | 0.81 | KAT7 (0.44) | KAT7KAT6ACYSLTR2CYSLTR1KAT6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4680226-A2 | ACYLSULFONAMIDE KAT6A INHIBITORS | Olema Pharmaceuticals, Inc. (US) | 2026-01-21 | — | — | EP | disclosed |
| US-20260015327-A1 | ACYLSULFONAMIDE KAT6A INHIBITORS | OLEMA PHARMACEUTICALS INC (US) | 2026-01-15 | — | — | US | disclosed |
| US-12428379-B2 | Acylsulfonamide KAT6A inhibitors | OLEMA PHARMACEUTICALS, INC. (US) | 2025-09-30 | — | — | US | disclosed |
| US-20250136553-A1 | ACYLSULFONAMIDE KAT6A INHIBITORS | OLEMA PHARMACEUTICALS, INC. | 2025-05-01 | — | — | US | disclosed |
| WO-2024189598-A2 | ACYLSULFONAMIDE KAT6A INHIBITORS | OLEMA PHARMACEUTICALS, INC. (US) | 2024-09-19 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250136553-A1 | ACYLSULFONAMIDE KAT6A INHIBITORS | KAT6A, KAT2A, KAT6B | KAT7 5/4885KAT6A 1/4885CYSLTR2 2573/4885 |
| US-12428379-B2 | Acylsulfonamide KAT6A inhibitors | KAT6A, KAT2A, KAT6B | KAT7 5/4885KAT6A 1/4885CYSLTR2 2573/4885 |
| US-20260015327-A1 | ACYLSULFONAMIDE KAT6A INHIBITORS | KAT6A, KAT2A, KAT6B | KAT7 4/4885KAT6A 1/4885CYSLTR2 3052/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.