Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 1/20 | 0.49 |
| ▸ | HTR2C | P28335 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 8/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3127088 | 0.98 | HTR2A (0.50) | HTR2AHTR2CALDH1A1MAPTMAPK1 | |
| SCHEMBL4006035 | 0.74 | HTR2C (0.69) | HTR2AHTR2CALDH1A1MAPTMAPK1 | |
| SCHEMBL4010697 | 0.74 | HTR2C (0.69) | HTR2AHTR2CALDH1A1MAPTMAPK1 | |
| SCHEMBL20365663 | 0.74 | HTR2A (0.53) | HTR2AHTR2CALDH1A1MAPTMAPK1 | |
| SCHEMBL19674675 | 0.73 | HTR2C (0.48) | HTR2AHTR2CALDH1A1MAPTMAPK1 | |
| SCHEMBL17984886 | 0.73 | HTR2C (0.59) | HTR2AHTR2CALDH1A1MAPTMAPK1 | |
| SCHEMBL4015795 | 0.72 | HTR2C (0.71) | HTR2AHTR2CALDH1A1MAPK1TDP1 | |
| Hydrochloric Acid SCHEMBL2905080 | 0.72 | HTR2C (0.57) | HTR2AHTR2CALDH1A1MAPTMAPK1 | |
| Hydrochloric Acid SCHEMBL2907812 | 0.70 | HTR2C (0.59) | HTR2AHTR2CALDH1A1MAPK1POLB | |
| SCHEMBL4337461 | 0.70 | HTR2A (0.48) | HTR2AHTR2CALDH1A1MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | claimed |
| WO-2010022055-A2 | INHIBITORS OF VOLTAGE-GATED SODIUM CHANNELS | AMGEN INC. (US) | 2010-02-25 | — | — | WO | disclosed |