Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2A6 | P11509 | 1/20 | 0.56 |
| ▸ | MAOA | P21397 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 1/20 | 0.56 |
| ▸ | NOS3 | P29474 | 2/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NOS2 | P35228 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 2/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | CES1 | P23141 | 1/20 | 0.44 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3193152 | 0.85 | CES1 (0.54) | CYP2A6MAOAMAOBNOS3TSHR | |
| SCHEMBL30505637 | 0.82 | CYP2A6 (0.68) | CYP2A6MAOAMAOBNOS3TSHR | |
| SCHEMBL3103992 | 0.82 | CYP2A6 (0.68) | CYP2A6MAOAMAOBNOS3TSHR | |
| SCHEMBL9652088 | 0.79 | CYP2A6 (0.65) | CYP2A6MAOAMAOBNOS3TSHR | |
| SCHEMBL30436320 | 0.79 | CYP2A6 (0.65) | CYP2A6MAOAMAOBNOS3TSHR | |
| SCHEMBL31430380 | 0.76 | TSHR (0.71) | CYP2A6MAOAMAOBNOS3TSHR | |
| SCHEMBL568779 | 0.76 | TSHR (0.71) | CYP2A6MAOAMAOBNOS3TSHR | |
| SCHEMBL31135519 | 0.74 | TSHR (0.67) | CYP2A6MAOAMAOBNOS3TSHR | |
| SCHEMBL31621255 | 0.74 | TSHR (0.67) | CYP2A6MAOAMAOBNOS3TSHR | |
| SCHEMBL30436120 | 0.74 | TSHR (0.67) | CYP2A6MAOAMAOBNOS3TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 36 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10919913-B2 | Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-02-16 | — | — | US | claimed |
| US-20190169209-A1 | NEW SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-06-06 | — | — | US | claimed |
| US-10246467-B2 | Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2019-04-02 | — | — | US | claimed |
| US-20170247394-A1 | SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2017-08-31 | — | — | US | claimed |
| EP-3183254-A1 | NEW SPIRO[3H-INDOLE-3,2´-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | Boehringer Ingelheim International GmbH (DE) | 2017-06-28 | — | — | EP | claimed |
| US-20160052938-A1 | SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-02-25 | — | — | US | claimed |
| WO-2016026937-A1 | NEW SPIRO[3H-INDOLE-3,2´-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2016-02-25 | — | — | WO | claimed |
| US-20240109913-A1 | NEW SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2024-04-04 | — | — | US | disclosed |
| US-20210101912-A1 | NEW SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2021-04-08 | — | — | US | disclosed |
| US-10919913-B2 | Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2021-02-16 | — | — | US | disclosed |
| CN-107001385-B | Spiro- [ 3H-indol-3, 2' -pyrrolidine ] -2(1H) -one compounds and derivatives thereof as MDM2-P53 inhibitors | 勃林格殷格翰国际有限公司 | 2020-03-13 | — | — | CN | disclosed |
| US-20190169209-A1 | NEW SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-06-06 | — | — | US | disclosed |
| EP-3183254-B1 | NEW SPIRO[3H-INDOLE-3,2´-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | BOEHRINGER INGELHEIM INT (DE) | 2019-05-22 | — | — | EP | disclosed |
| WO-2007101347-A1 | BIR DOMAIN BINDING COMPOUNDS | AEGERA THERAPEUTICS INC. (CA) | 2007-09-13 | — | — | WO | disclosed |
| EP-1000930-A2 | Tachykinin antagonists | WARNER-LAMBERT COMPANY (US) | 2000-05-17 | — | — | EP | disclosed |
| US-5981755-A | Tachykinin antagonists | WARNER-LAMBERT COMPANY (US) | 1999-11-09 | — | — | US | disclosed |
| US-5856354-A | RESPIRATORY SYSTEM DISORDERS, ANTIINFLAMMATORY AGENTS, GASTROINTESTINAL DISORDERS, VISION DEFECTS, ANTIALLERGENS,PAIN, NERVOUS SYSTEM DISORDERS, HEADACHES | WARNER-LAMBERT COMPANY (US) | 1999-01-05 | — | — | US | disclosed |
| US-5716979-A | NONPEPTIDES, UNIQUE IN ALKYLATION/SUBSTITUTION PATTERN ALONG THEIR BACKBONE, USEFUL FOR TREATING DISORDERS SUCH AS RESPIRATORY, INFLAMMATORY, GASTROINTESTINAL, OPHTHALMIC, ALLERGIES, PAIN, VASCULAR, MIGRANE, ARTHRITIS AND BRAIN | WARNER-LAMBERT COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| US-5594022-A | CARBAMATES | WARNER-LAMBERT COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| WO-1994004494-A1 | TACHYKININ ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1994-03-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160052938-A1 | SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | TP53, MDM2, FOXM1 | CYP2A6 1548/4885MAOA 1533/4885MAOB 1562/4885 |
| US-20210101912-A1 | NEW SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | TP53, MDM2, FOXM1 | CYP2A6 1565/4885MAOA 1604/4885MAOB 1560/4885 |
| US-10919913-B2 | Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors | TP53, MDM2, FOXM1 | CYP2A6 1373/4885MAOA 1451/4885MAOB 1533/4885 |
| US-20170247394-A1 | SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | TP53, MDM2, FOXM1 | CYP2A6 1390/4885MAOA 1401/4885MAOB 1486/4885 |
| US-20190169209-A1 | NEW SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | TP53, MDM2, FOXM1 | CYP2A6 1565/4885MAOA 1604/4885MAOB 1560/4885 |
| US-20240109913-A1 | NEW SPIRO[3H-INDOLE-3,2'-PYRROLIDIN]-2(1H)-ONE COMPOUNDS AND DERIVATIVES AS MDM2-P53 INHIBITORS | TP53, MDM2, FOXM1 | CYP2A6 1565/4885MAOA 1604/4885MAOB 1560/4885 |
| US-10246467-B2 | Spiro[3H-indole-3,2′-pyrrolidin]-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors | TP53, MDM2, FOXM1 | CYP2A6 1373/4885MAOA 1451/4885MAOB 1533/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.