Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | CHKA | P35790 | 1/20 | 0.39 |
| ▸ | CHKB | Q9Y259 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31184397 | 0.92 | POLB (0.45) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL31184653 | 0.90 | POLB (0.42) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL31184597 | 0.90 | POLB (0.41) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL31184940 | 0.90 | CHKA (0.42) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL31184656 | 0.88 | POLB (0.40) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL31184644 | 0.88 | MAPT (0.43) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL31184652 | 0.87 | POLB (0.39) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL31184365 | 0.87 | POLB (0.42) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL31184884 | 0.87 | POLB (0.43) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL31184406 | 0.87 | POLB (0.43) | POLBSMN1; SMN2ALDH1A1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024220626-A1 | SMALL MOLECULE MODULATORS OF OGG1 | AZKARRA THERAPEUTICS, INC. (US) | 2024-10-24 | — | — | WO | disclosed |