Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.39 |
| ▸ | CHKB | Q9Y259 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | ROS1 | P08922 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | MALT1 | Q9UDY8 | 3/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31184952 | 0.91 | CHKA (0.37) | CHKACHKBPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL31184592 | 0.91 | CHKA (0.41) | CHKACHKBPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL31184717 | 0.88 | POLB (0.39) | CHKACHKBPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL31185123 | 0.86 | CHKA (0.46) | CHKACHKBPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL31185015 | 0.84 | CHKA (0.40) | CHKACHKBPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL31184841 | 0.84 | POLB (0.45) | CHKACHKBPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL31184359 | 0.83 | POLB (0.47) | CHKACHKBPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL31184722 | 0.83 | POLB (0.38) | CHKACHKBPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL31184756 | 0.82 | POLB (0.43) | CHKACHKBPOLBSMN1; SMN2ALDH1A1 | |
| SCHEMBL31184644 | 0.81 | MAPT (0.43) | CHKACHKBPOLBSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024220626-A1 | SMALL MOLECULE MODULATORS OF OGG1 | AZKARRA THERAPEUTICS, INC. (US) | 2024-10-24 | — | — | WO | disclosed |