Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM4 | O15151 | 3/20 | 0.46 |
| ▸ | TP53 | P04637 | 3/20 | 0.46 |
| ▸ | MDM2 | Q00987 | 7/20 | 0.46 |
| ▸ | SLC17A5 | Q9NRA2 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19410224 | 1.00 | MDM4 (0.46) | MDM4TP53MDM2SLC17A5CASP3 | |
| SCHEMBL32664869 | 0.91 | MDM4 (0.48) | MDM4TP53MDM2SLC17A5CASP3 | |
| SCHEMBL30002165 | 0.91 | MDM4 (0.48) | MDM4TP53MDM2SLC17A5CASP3 | |
| SCHEMBL30959635 | 0.91 | MDM4 (0.48) | MDM4TP53MDM2SLC17A5CASP3 | |
| SCHEMBL16100700 | 0.91 | MDM4 (0.48) | MDM4TP53MDM2SLC17A5CASP3 | |
| SCHEMBL16100697 | 0.91 | MDM4 (0.48) | MDM4TP53MDM2SLC17A5CASP3 | |
| SCHEMBL25356586 | 0.88 | MDM4 (0.48) | MDM4TP53MDM2SLC17A5CASP3 | |
| SCHEMBL31370257 | 0.88 | MDM4 (0.48) | MDM4TP53MDM2SLC17A5CASP3 | |
| SCHEMBL25356592 | 0.88 | MDM4 (0.48) | MDM4TP53MDM2SLC17A5CASP3 | |
| SCHEMBL19410153 | 0.87 | MDM4 (0.46) | MDM4TP53MDM2SLC17A5CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3440097-B1 | MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80/PD-L1 PROTEIN/PROTEIN INTERACTIONS | BRISTOL MYERS SQUIBB CO (US) | 2024-10-23 | — | — | EP | disclosed |