SCHEMBL31190

SCHEMBL31190

CC(C)C1CCCN1Cc1ccc(/C=C/C(=O)NO)cc1

nearest known ligand 0.51

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 14/20 0.51
KCNH2 Q12809 6/20 0.51
HDAC6 Q9UBN7 9/20 0.49
HDAC3 O15379 8/20 0.49
HDAC8 Q9BY41 8/20 0.49
HDAC4 P56524 7/20 0.49
HDAC5 Q9UQL6 7/20 0.49
HDAC2 Q92769 7/20 0.49
HDAC7 Q8WUI4 6/20 0.49
HDAC10 Q969S8 6/20 0.49
HDAC11 Q96DB2 6/20 0.49
HDAC9 Q9UKV0 6/20 0.49
NPC1 O15118 1/20 0.46
RAB9A P51151 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
KDM1A O60341 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2734193 0.84 HDAC1 (0.56) HDAC1KCNH2HDAC6HDAC3HDAC8
SCHEMBL18565 0.84 HDAC1 (0.56) HDAC1KCNH2HDAC6HDAC3HDAC8
SCHEMBL30078 0.81 HDAC1 (0.48) HDAC1KCNH2HDAC6HDAC3HDAC8
SCHEMBL30077 0.81 HDAC1 (0.48) HDAC1KCNH2HDAC6HDAC3HDAC8
SCHEMBL2733125 0.77 HDAC1 (0.64) HDAC1KCNH2HDAC6HDAC3HDAC8
SCHEMBL20023 0.77 HDAC1 (0.64) HDAC1KCNH2HDAC6HDAC3HDAC8
SCHEMBL1779274 0.76 HDAC1 (0.58) HDAC1KCNH2HDAC6HDAC3HDAC8
SCHEMBL1779275 0.76 HDAC1 (0.58) HDAC1KCNH2HDAC6HDAC3HDAC8
SCHEMBL1779648 0.76 HDAC1 (0.58) HDAC1KCNH2HDAC6HDAC3HDAC8
SCHEMBL1779270 0.76 HDAC1 (0.58) HDAC1KCNH2HDAC6HDAC3HDAC8

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012025164-A1 HYDROXAMATE-BASED INHIBITORS OF DEACETYLASES NOVARTIS AG (CH) 2012-03-01 WO disclosed