Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 1/20 | 0.38 |
| ▸ | NTRK1 | P04629 | 7/20 | 0.36 |
| ▸ | PLK4 | O00444 | 2/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.36 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.36 |
| ▸ | AURKA | O14965 | 6/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 4/20 | 0.35 |
| ▸ | SYK | P43405 | 4/20 | 0.35 |
| ▸ | RET | P07949 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1298579 | 0.88 | DHODH (0.40) | DHODHNTRK1PLK4PAK4NTRK3 | |
| SCHEMBL1298510 | 0.88 | DHODH (0.40) | DHODHNTRK1PLK4PAK4NTRK3 | |
| SCHEMBL1299082 | 0.88 | DHODH (0.40) | DHODHNTRK1PLK4PAK4NTRK3 | |
| SCHEMBL1299104 | 0.88 | DHODH (0.38) | DHODHNTRK1PLK4PAK4NTRK3 | |
| SCHEMBL1299555 | 0.86 | DHODH (0.40) | DHODHNTRK1PLK4PAK4NTRK3 | |
| SCHEMBL1298720 | 0.86 | DHODH (0.38) | DHODHNTRK1PLK4PAK4NTRK3 | |
| SCHEMBL1299140 | 0.85 | RET (0.40) | DHODHNTRK1PLK4PAK4NTRK3 | |
| SCHEMBL1298754 | 0.85 | DHODH (0.44) | DHODHNTRK1PLK4PAK4NTRK3 | |
| SCHEMBL1298991 | 0.84 | DHODH (0.37) | DHODHNTRK1PLK4PAK4NTRK3 | |
| SCHEMBL1298034 | 0.83 | NTRK1 (0.37) | DHODHNTRK1PLK4PAK4NTRK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010002472-A1 | JAK KINASE MODULATING COMPOUNDS AND METHODS OF USE THEREOF | AMBIT BIOSCIENCES CORPORATION (US) | 2010-01-07 | — | — | WO | disclosed |